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Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies
文献类型：期刊论文
| 作者 | Shi, Feng1; Liu, Bing1 ; Zhou, Yuan1; Yu, Chunshui2; Jiang, Tianzi1
|
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2009 |
| 卷号 | 19期号:11页码:1055-1064 |
| 关键词 | magnetic resonance imaging hippocampus volumetric analysis asymmetry meta-analysis |
| 英文摘要 | Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left-right asymmetry of the hippocampus receives less research attention. In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72-1.11] and right (ES, 0.78, 95% CI, 0.57-0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37-1.84, in left; ES, 1.52, 95% Cl, 1.31-1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group. (C) 2009 Wiley-Liss, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | MEDIAL TEMPORAL-LOBE ; CEREBROVASCULAR-DISEASE ; MEMORY PERFORMANCE ; ENTORHINAL CORTEX ; AMYGDALAR VOLUME ; DELAYED RECALL ; SHAPE-ANALYSIS ; ATROPHY ; DEMENTIA ; SCHIZOPHRENIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271566100002 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9976]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Feng,Liu, Bing,Zhou, Yuan,et al. Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies[J]. HIPPOCAMPUS,2009,19(11):1055-1064. |
| APA | Shi, Feng,Liu, Bing,Zhou, Yuan,Yu, Chunshui,&Jiang, Tianzi.(2009).Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies.HIPPOCAMPUS,19(11),1055-1064. |
| MLA | Shi, Feng,et al."Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies".HIPPOCAMPUS 19.11(2009):1055-1064. |
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来源：自动化研究所
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