Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy
文献类型：期刊论文
| 作者 | Liu, Renfa1; Jing, Lijia1,3; Peng, Dong2; Li, Yong3 ; Tian, Jie2; Dai, Zhifei1
|
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:10页码:1144-1153 |
| 关键词 | Copper sulfide nanoparticles Nanotheranostic agent Photoacoustic imaging Magnatic resonance imaging Photothermal therapy |
| 英文摘要 | The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | MRI CONTRAST AGENTS ; IN-VIVO ; SYNERGISTIC THERAPY ; THERANOSTIC AGENT ; CANCER-CELLS ; ABLATION ; PLATFORM ; PROBE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359472700008 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/8914]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Renfa,Jing, Lijia,Peng, Dong,et al. Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy[J]. THERANOSTICS,2015,5(10):1144-1153. |
| APA | Liu, Renfa,Jing, Lijia,Peng, Dong,Li, Yong,Tian, Jie,&Dai, Zhifei.(2015).Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.THERANOSTICS,5(10),1144-1153. |
| MLA | Liu, Renfa,et al."Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy".THERANOSTICS 5.10(2015):1144-1153. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。