The neurobiological drive for overeating implicated in Prader-Willi syndrome
文献类型：期刊论文
| 作者 | Zhang, Yi1,2,3; Wang, Jing1; Zhang, Guansheng1; Zhu, Qiang1; Cai, Weiwei1; Tian, Jie1,4 ; Zhang, Yi Edi2,3,5; Miller, Jennifer L.6; Wen, Xiaotong7; Ding, Mingzhou9
|
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2015-09-16 |
| 卷号 | 1620页码:72-80 |
| 关键词 | PWS Overeating Obesity Granger causality Resting-state fMRI |
| 英文摘要 | Prader-Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous fMRI studies examined the activation of eating-related neural circuits in PWS patients with or without exposures to food cues and found an excessive eating motivation and a reduced inhibitory control of cognitive processing of food. However, the effective connectivity between various brain areas or neural circuitry critically implicated in both the biological and behavioral control of overeating in PWS is largely unexplored. The current study combined resting-state fMRI and Granger causality analysis (GCA) techniques to investigate interactive causal influences among key neural pathways underlying overeating in PWS. We first defined the regions of interest (ROIs) that demonstrated significant alterations of the baseline brain activity levels in children with PWS (n=21) as compared to that of their normal siblings controls (n=18), and then carried out GCA to characterize the region-to-region interactions among these ROIs. Our data revealed significantly enhanced causal influences from the amygdala to the hypothalamus and from both the medial prefrontal cortex and anterior cingulate cortex to the amygdala in patients with PWS (P<0.001). These alterations offer new explanations for hypothalamic regulation of homeostatic energy intake and impairment in inhibitory control circuit. The deficits in these dual aspects may jointly contribute to the extreme hyperphagia in PWS. This study provides both a new methodological and a neurobiological perspective to aid in a better understanding of neural mechanisms underlying obesity in the general public. This article is part of a Special Issue entitled 1618. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | ANTERIOR CINGULATE CORTEX ; LOW-CALORIE FOODS ; ORBITOFRONTAL CORTEX ; INCENTIVE MOTIVATION ; GRANGER CAUSALITY ; HUMAN AMYGDALA ; LEARNED CUES ; NEURAL BASIS ; OBESITY ; CIRCUITRY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361162800006 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/8981]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA 3.Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 5.Malcom Randall Vet Affairs Med Ctr, Gainesville, FL 32608 USA 6.Univ Florida, Dept Pediat, Gainesville, FL 32610 USA 7.Remin Univ China, Dept Psychol, Beijing 100872, Peoples R China 8.Southwest Univ, Dept Psychol, Chongqing 400715, Peoples R China 9.Univ Florida, Dept Biomed Engn, Gainesville, FL 32610 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Yi,Wang, Jing,Zhang, Guansheng,et al. The neurobiological drive for overeating implicated in Prader-Willi syndrome[J]. BRAIN RESEARCH,2015,1620:72-80. |
| APA | Zhang, Yi.,Wang, Jing.,Zhang, Guansheng.,Zhu, Qiang.,Cai, Weiwei.,...&Liu, Yijun.(2015).The neurobiological drive for overeating implicated in Prader-Willi syndrome.BRAIN RESEARCH,1620,72-80. |
| MLA | Zhang, Yi,et al."The neurobiological drive for overeating implicated in Prader-Willi syndrome".BRAIN RESEARCH 1620(2015):72-80. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。