Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method
文献类型：期刊论文
| 作者 | Liu, Haixiao1,2 ; Yang, Xin1,2; Song, Tianming1; Bao, Chengpeng1; Shi, Liangliang1,2; Hu, Zhenhua1,2; Wang, Kun1,2; Tian, Jie1,2
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| 刊名 | JOURNAL OF BIOMEDICAL OPTICS
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| 出版日期 | 2015-08-01 |
| 卷号 | 20期号:8 |
| 关键词 | Cerenkov luminescence tomography spherical harmonics approximation multispectral diffusion theory |
| 英文摘要 | Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional non-invasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | MOUSE MODEL ; LIGHT ; RADIOTRACERS ; PET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362516700018 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/10040]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Haixiao,Yang, Xin,Song, Tianming,et al. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8). |
| APA | Liu, Haixiao.,Yang, Xin.,Song, Tianming.,Bao, Chengpeng.,Shi, Liangliang.,...&Tian, Jie.(2015).Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method.JOURNAL OF BIOMEDICAL OPTICS,20(8). |
| MLA | Liu, Haixiao,et al."Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015). |
入库方式： OAI收割
来源：自动化研究所
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