A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics
文献类型：期刊论文
| 作者 | Jiang, Qiao1; Shi, Yuefeng2; Zhang, Qian3 ; Li, Na1; Zhan, Pengfei1; Song, Linlin1; Dai, Luru1; Tian, Jie3; Du, Yang3; Cheng, Zhen4
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| 刊名 | SMALL
 |
| 出版日期 | 2015-10-14 |
| 卷号 | 11期号:38页码:5134-5141 |
| 英文摘要 | A self-assembled DNA origami (DO)-gold nanorod (GNR) complex, which is a dual-functional nanotheranostics constructed by decorating GNRs onto the surface of DNA origami, is demonstrated. After 24 h incubation of two structured DO-GNR complexes with human MCF7 breast cancer cells, significant enhancement of cell uptake is achieved compared to bare GNRs by two-photon luminescence imaging. Particularly, the triangle shaped DO-GNR complex exhibits optimal cellular accumulation. Compared to GNRs, improved photothermolysis against tumor cells is accomplished for the triangle DO-GNR complex by two-photon laser or NIR laser irradiation. Moreover, the DO-GNR complex exhibits enhanced antitumor efficacy compared with bare GNRs in nude mice bearing breast tumor xenografts. The results demonstrate that the DO-GNR complex can achieve optimal two-photon cell imaging and photothermal effect, suggesting a promising candidate for cancer diagnosis and therapy both in vitro and in vivo. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | PHOTOTHERMAL THERAPY PPTT ; DRUG-DELIVERY ; NANOPARTICLES ; NANOSTRUCTURES ; NANOTECHNOLOGY ; CARCINOMA ; PLATFORM ; SHAPES ; CELLS ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362819700017 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/10334]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, CAS Key Lab Nanosyst & Hierarchial Fabricat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Stanford Univ, Dept Radiol, Lucas Ctr, Stanford, CA 94305 USA |
| 推荐引用方式 GB/T 7714 | Jiang, Qiao,Shi, Yuefeng,Zhang, Qian,et al. A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics[J]. SMALL,2015,11(38):5134-5141. |
| APA | Jiang, Qiao.,Shi, Yuefeng.,Zhang, Qian.,Li, Na.,Zhan, Pengfei.,...&Ding, Baoquan.(2015).A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics.SMALL,11(38),5134-5141. |
| MLA | Jiang, Qiao,et al."A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics".SMALL 11.38(2015):5134-5141. |
入库方式： OAI收割
来源：自动化研究所
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