Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies
文献类型：期刊论文
| 作者 | Han, Jun; Jiang, Yi; Liu, Xiao; Meng, Qingyang; Xi, Qiulei; Zhuang, Qiulin; Han, Yusong; Gao, Ying（高莹） ; Ding, QiuRong（丁秋蓉）; Wu, Guohao
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| 刊名 | PLOS ONE
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| 出版日期 | 2015 |
| 卷号 | 10期号:9页码:e0138580 |
| 通讯作者 | Wu, GH (reprint author), Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Clin Nutr Ctr Shanghai, Shanghai 200433, Peoples R China. |
| 英文摘要 | Background and Objectives Consumption of dietary fat has been reported to be associated with gastric cancer risk, but the results of epidemiologic studies remain inconsistent. We conducted a meta-analysis to summarize the evidence regarding the association between dietary fat intake and gastric cancer risk. Methods A comprehensive search of PubMed and EMBASE was performed to identify observational studies providing quantitative estimates between dietary fat and gastric cancer risk. Random effects model was used to calculate the summary relative risk(SRR) in the highest versus lowest analysis. Categorical dose-response analysis was conducted to quantify the association between dietary fat intake and gastric cancer risk. Heterogeneity among studies was evaluated using I-2 and tau2(between study variance) statistics. Subgroup analysis and publication bias analysis were also performed. Results Twenty-two articles were included in the meta-analysis. The SRR for gastric cancer was 1.18 for individuals with highest intake versus lowest intake of total fat (95% confidence interval [CI]: 0.999-1.39; n = 28; P< 0.001; tau(2) = 0.12; I-2 = 69.5%, 95% CI: 55%-79%) and 1.08 with a daily increase in total fat intake (20 g/d) (95% CI: 1.02-1.14; n = 6; P = 0.09; tau(2) = 0.002; I-2 = 46.8%, 95% CI: 0%-79%). Positive association between saturated fat intake (SRR = 1.31; 95% CI: 1.09-1.58; n = 18; P<0.001; tau(2) = 0.08; I-2 = 60.6%, 95% CI: 34%-76%), inverse association between polyunsaturated fat intake (SRR = 0.77; 95% CI: 0.65-0.92; n = 16; P = 0.003; tau(2) = 0.06; I-2 = 56.2%, 95% CI: 23%-75%) and vegetable fat intake (SRR = 0.55; 95% CI: 0.41-0.74; n = 4; P = 0.12; tau(2) = 0.04; I-2 = 48.6%, 95% CI: 0%-83%), and no association between monounsaturated fat intake (SRR = 1.00; 95% CI: 0.79-1.25; n = 14; P< 0.001; tau(2) = 0.10; I-2 = 63.0%, 95% CI: 34%-79%) and animal fat intake (SRR = 1.10; 95% CI: 0.90-1.33; n = 6; P = 0.13; tau(2) = 0.02; I-2 = 42.0%, 95% CI: 0%-70%) and gastric cancer risk were observed. Conclusions Our results suggest that intake of total fat is potentially positively associated with gastric cancer risk, and specific subtypes of fats account for different effects. However, these findings should be confirmed by further well-designed cohort studieswith detailed dietary assessments and strict control of confounders. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DOSE-RESPONSE DATA ; COLORECTAL-CANCER ; NUTRIENT INTAKE ; BREAST-CANCER ; STOMACH-CANCER ; HELICOBACTER-PYLORI ; NUTRITIONAL FACTORS ; PANCREATIC-CANCER ; TREND ESTIMATION ; AARP DIET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361798100030 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/386]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_表观遗传学和营养相关慢性病研究组 中国科学院上海生命科学研究院营养科学研究所_代谢疾病与遗传研究组 |
| 推荐引用方式 GB/T 7714 | Han, Jun,Jiang, Yi,Liu, Xiao,et al. Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies[J]. PLOS ONE,2015,10(9):e0138580. |
| APA | Han, Jun.,Jiang, Yi.,Liu, Xiao.,Meng, Qingyang.,Xi, Qiulei.,...&Wu, Guohao.(2015).Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies.PLOS ONE,10(9),e0138580. |
| MLA | Han, Jun,et al."Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies".PLOS ONE 10.9(2015):e0138580. |
入库方式： OAI收割
来源：上海营养与健康研究所
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