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Urinary Prostaglandin E-2 Metabolite and Pancreatic Cancer Risk: Case-Control Study in Urban Shanghai
文献类型：期刊论文
| 作者 | Zhao, Jing（赵晶）; Wang, Jing; Du, Jinfeng; Xu, Hongli; Zhang, Wei; Ni, Quan-Xing; Yu, Herbert; Risch, Harvey A.; Gao, Yu-Tang; Gao, Ying（高莹）
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| 刊名 | PLOS ONE
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| 出版日期 | 2015 |
| 卷号 | 10期号:2页码:e0118004 |
| 通讯作者 | Gao, YT (reprint author), Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Epidemiol,Shanghai Canc Inst, Shanghai 200030, Peoples R China. |
| 英文摘要 | Pancreatic cancer has been increasing in importance in Shanghai over the last four decades. The etiology of the disease is still unclear. Evidence suggests that the COX-2 pathway, an important component of inflammation, may be involved in the disease. We aimed to evaluate the association between urinary prostaglandin E-2 metabolite (PGE-M) level and risk of pancreatic cancer. From a recent population-based case-control study in Shanghai, 200 pancreatic ductal adenocarcinoma cases and 200 gender-and age-frequency matched controls were selected for the present analysis. Urinary PGE-M was measured with a liquid chromatography/mass spectrometric assay. Adjusted unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A positive association was observed between PGE-M leve and pancreatic cancer risk: OR = 1.63 (95% CI 1.01-2.63) for the third tertile compared to the first. Though the interactions were not statistically significant, the associations tended to be stronger among subjects with diabetes history (OR = 3.32; 95% CI 1.20-9.19) and higher meat intake (OR = 2.12; 95% CI 1.10-4.06). The result suggests that higher urinary PGE-M level may be associated with increased risk of pancreatic ductal adenocarcinoma. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; CYCLOOXYGENASE-2 EXPRESSION ; ARACHIDONIC-ACID ; BREAST-CANCER ; INTRAEPITHELIAL NEOPLASIA ; PGE-M ; INFLAMMATION ; ASSOCIATION ; METAANALYSIS ; EICOSANOIDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350682600100 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/387]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_表观遗传学和营养相关慢性病研究组 |
| 推荐引用方式 GB/T 7714 | Zhao, Jing,Wang, Jing,Du, Jinfeng,et al. Urinary Prostaglandin E-2 Metabolite and Pancreatic Cancer Risk: Case-Control Study in Urban Shanghai[J]. PLOS ONE,2015,10(2):e0118004. |
| APA | Zhao, Jing.,Wang, Jing.,Du, Jinfeng.,Xu, Hongli.,Zhang, Wei.,...&Gao, Ying.(2015).Urinary Prostaglandin E-2 Metabolite and Pancreatic Cancer Risk: Case-Control Study in Urban Shanghai.PLOS ONE,10(2),e0118004. |
| MLA | Zhao, Jing,et al."Urinary Prostaglandin E-2 Metabolite and Pancreatic Cancer Risk: Case-Control Study in Urban Shanghai".PLOS ONE 10.2(2015):e0118004. |
入库方式： OAI收割
来源：上海营养与健康研究所
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