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  5. 糖脂代谢与调控研究组
Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure

文献类型：期刊论文

作者Zhang, Qian; Liu, Bin; Cheng, Ying; Meng, Qingshu; Xia, Tingting; Jiang, Lei; Chen, Shanghai（陈上海）; Liu, Yong（刘勇）; Guo, Feifan（郭非凡）
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
出版日期2014
卷号289期号:3页码:1779-1787
关键词Energy Metabolism Hypothalamus Leptin STAT3 Uncoupling Proteins Fat Loss Leucine Deprivation
通讯作者Liu, Y (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci,Shanghai Inst Biol Sci,Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
英文摘要Background: Leucine deprivation decreases fat mass via enhancing energy expenditure; the involvement of leptin signaling is unknown. Results: Leucine deprivation promoted leptin signaling, and the increased energy expenditure was blocked in leptin signaling-disrupted mice. Conclusion: Leptin signaling is required for leucine deprivation-increased energy expenditure. Significance: Our studies reveal a physiological mechanism linking leptin signaling with leucine deprivation-enhanced energy expenditure. Leptin signaling in the hypothalamus is crucial in energy homeostasis. We have previously shown that dietary deprivation of the essential amino acid leucine in mice stimulates fat loss by increasing energy expenditure. The involvement of leptin signaling in this regulation, however, has not been reported. Here, we show that leucine deprivation promotes leptin signaling in mice maintained on an otherwise normal diet and restores leptin responses in mice maintained on a high fat diet, a regimen known to induce leptin resistance. In addition, we found that leucine deprivation stimulated energy expenditure, and fat loss was largely blocked in db/db mice homozygous for a mutation in leptin receptor and a knock-in mouse line Y3F with abrogation of leptin receptor Tyr(1138)-mediated signal transducer and activator transcript 3 signaling. Overall, our studies describe a novel link between hypothalamic leptin signaling and stimulation of energy expenditure under leucine deprivation.
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]RECEPTOR MESSENGER-RNA ; DIET-INDUCED OBESITY ; HIGH-FAT ; PLASMA LEPTIN ; FOOD-INTAKE ; LONG FORM ; GLUCOSE-TOLERANCE ; NERVOUS-SYSTEM ; AMINO-ACID ; L-ARGININE
收录类别SCI
语种英语
WOS记录号WOS:000332401700048
公开日期2015-12-24
版本出版稿
源URL[http://202.127.25.144/handle/331004/278]  
专题中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组
中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组
推荐引用方式
GB/T 7714		 Zhang, Qian,Liu, Bin,Cheng, Ying,et al. Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2014,289(3):1779-1787.
APA Zhang, Qian.,Liu, Bin.,Cheng, Ying.,Meng, Qingshu.,Xia, Tingting.,...&Guo, Feifan.(2014).Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure.JOURNAL OF BIOLOGICAL CHEMISTRY,289(3),1779-1787.
MLA Zhang, Qian,et al."Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure".JOURNAL OF BIOLOGICAL CHEMISTRY 289.3(2014):1779-1787.

入库方式： OAI收割

来源：上海营养与健康研究所

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