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BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells
文献类型：期刊论文
| 作者 | Zhou, Xuexia; Li, Xuebing; Cheng, Yuanming; Wu, Wenwu; Xie, Zhiqin（谢直勤）; Xi, Qiulei; Han, Jun; Wu, Guohao; Fang, Jing（方靖）; Feng, Ying（冯英）
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:0页码:4581 |
| 通讯作者 | Feng, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, 320 Yueyang Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Bcl-2-associated transcription factor 1 (BCLAF1) is known to be involved in multiple biological processes. Although several splice variants of BCLAF1 have been identified, little is known about how BCLAF1 splicing is regulated or the contribution of alternative splicing to its developmental functions. Here we find that inclusion of alternative exon5a was significantly increased in colorectal cancer (CRC) samples. Knockdown of the BCLAF1 protein isoform resulting from exon5a inclusion inhibited growth and that its overexpression increased tumorigenic potential. We also found that the splicing factor SRSF10 stimulates inclusion of exon5a and has growth-inducing activity. Importantly, the upregulation of SRSF10 expression observed in clinical CRC samples parallels the increased inclusion of BCLAF1 exon5a, both of which are associated with higher tumour grade. These findings identify SRSF10 as a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | PROMOTING TRANSCRIPTIONAL REPRESSOR ; COLORECTAL-CANCER ; GENE-EXPRESSION ; BINDING ; SRP38 ; ANGIOGENESIS ; PROTEINS ; INSIGHTS ; NETWORKS ; PATHWAYS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341052900008 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/330]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 中国科学院上海生命科学研究院营养科学研究所_代谢性疾病的基因表达调控研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Xuexia,Li, Xuebing,Cheng, Yuanming,et al. BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells[J]. NATURE COMMUNICATIONS,2014,5(0):4581. |
| APA | Zhou, Xuexia.,Li, Xuebing.,Cheng, Yuanming.,Wu, Wenwu.,Xie, Zhiqin.,...&Feng, Ying.(2014).BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells.NATURE COMMUNICATIONS,5(0),4581. |
| MLA | Zhou, Xuexia,et al."BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells".NATURE COMMUNICATIONS 5.0(2014):4581. |
入库方式： OAI收割
来源：上海营养与健康研究所
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