Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F-2 alpha Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population
文献类型：期刊论文
| 作者 | Xiao, Bing; Gu, Shui-Ming; Li, Mulin Jun; Li, Jun; Tao, Bo; Wang, Yuanyang; Wang, Yan; Zuo, Shengkai; Shen, Yujun; Yu, Yu |
| 刊名 | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 35期号:7页码:1687-1695 |
| 关键词 | hypertension essential microRNAs polymorphism single nucleotide prostaglandin F-2 receptor |
| 通讯作者 | Yu, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Objective To investigate whether rs12731181 (AG) interrupted miR-590-3p-mediated suppression of the prostaglandin F-2 receptor (FP) and whether it is associated with essential hypertension in the Chinese population. Approach and Results We found that miR-590-3p regulates human FP gene expression by binding to its 3-untranslated region. rs12731181 (AG) altered the binding affinity between miR-590-3p and its FP 3-untranslated region target, thus reducing the suppression of FP expression, which, in turn, enhanced FP receptor-mediated contractility of vascular smooth muscle cells. Overexpression of FP augmented vascular tone and elevated blood pressure in mice. An association study was performed to analyze the relationship between the FP gene and essential hypertension in the Han Chinese population. The results indicated that the rs12731181 G allele was associated with susceptibility to essential hypertension. Carriers of the AG genotype exhibited significantly higher blood pressure than those of the AA genotype. FP gene expression was significantly higher in human peripheral leukocytes from individuals with the AG genotype than that in leukocytes from individuals with the AA genotype. Conclusions rs12731181 in the seed region of the miR-590-3p target site is associated with increased risk of essential hypertension and represents a new paradigm for FP involvement in blood pressure regulation. |
| 类目[WOS] | Hematology ; Peripheral Vascular Disease |
| 研究领域[WOS] | Hematology ; Cardiovascular System & Cardiology |
| 关键词[WOS] | SMOOTH-MUSCLE-CELLS ; BLOOD-PRESSURE ; CARDIOVASCULAR-DISEASE ; NEOINTIMAL FORMATION ; UNTRANSLATED REGION ; EP2 RECEPTOR ; PROSTACYCLIN ; EXPRESSION ; PHENOTYPE ; MICRORNAS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356867300018 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/270]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 中国科学院上海生命科学研究院营养科学研究所_磷脂代谢与心血管疾病研究组 |
| 推荐引用方式 GB/T 7714 | Xiao, Bing,Gu, Shui-Ming,Li, Mulin Jun,et al. Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F-2 alpha Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2015,35(7):1687-1695. |
| APA | Xiao, Bing.,Gu, Shui-Ming.,Li, Mulin Jun.,Li, Jun.,Tao, Bo.,...&Yu, Ying.(2015).Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F-2 alpha Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,35(7),1687-1695. |
| MLA | Xiao, Bing,et al."Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F-2 alpha Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35.7(2015):1687-1695. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。