Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption
文献类型：期刊论文
| 作者 | Ye, Kaixiong; Cao, Chang; Lin, Xu（林旭） ; O'Brien, Kimberly O.; Gu, Zhenglong
|
| 刊名 | BMC GENETICS
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:1页码:61 |
| 关键词 | Adaptation Iron Homeostasis Absorption HFE |
| 通讯作者 | O'Brien, KO (reprint author), Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA. |
| 英文摘要 | Background: HFE, a major regulator of iron (Fe) homeostasis, has been suggested to be under positive selection in both European and Asian populations. While the genetic variant under selection in Europeans (a non-synonymous mutation, C282Y) has been relatively well-studied, the adaptive variant in Asians and its functional consequences are still unknown. Identifying the adaptive HFE variants in Asians will not only elucidate the evolutionary history and the genetic basis of population difference in Fe status, but also assist the future practice of genome-informed dietary recommendation. Results: Using data from the International HapMap Project, we confirmed the signatures of positive selection on HFE in Asian populations and identified a candidate adaptive haplotype that is common in Asians (52.35-54.71 %) but rare in Europeans (5.98 %) and Africans (4.35 %). The T allele at tag SNP rs9366637 (C/T) captured 95.8 % of this Asian-common haplotype. A significantly reduced HFE expression was observed in individuals carrying T/T at rs9366637 compared to C/C and C/T, indicating a possible role of gene regulation in adaptation. We recruited 57 women of Asian descent and measured Fe absorption using stable isotopes in those homozygous at rs9366637. We observed a 22 % higher absorption in women homozygous for the Asian-common haplotype (T/T) compared to the control genotype (C/C). Additionally, compared with a group of age-matched Caucasian women, Asian women exhibited significantly elevated Fe absorption. Conclusions: Our results indicate parallel adaptation of HFE gene in Europeans and Asians with different genetic variants. Moreover, natural selection on HFE may have contributed to elevated Fe absorption in Asians. This study regarding population differences in Fe homeostasis has significant medical impact as high Fe level has been linked to an increased disease risk of metabolic syndromes. |
| 类目[WOS] | Genetics & Heredity |
| 研究领域[WOS] | Genetics & Heredity |
| 关键词[WOS] | RED-BLOOD-CELL ; HEREDITARY HEMOCHROMATOSIS ; C282Y MUTATION ; TRANSFERRIN RECEPTOR ; GENETIC-VARIATION ; ELDERLY CHINESE ; PLASMA FERRITIN ; SERUM HEPCIDIN ; HUMAN GENOME ; DEFICIENCY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356131700001 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/176]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Ye, Kaixiong,Cao, Chang,Lin, Xu,et al. Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption[J]. BMC GENETICS,2015,16(1):61. |
| APA | Ye, Kaixiong,Cao, Chang,Lin, Xu,O'Brien, Kimberly O.,&Gu, Zhenglong.(2015).Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption.BMC GENETICS,16(1),61. |
| MLA | Ye, Kaixiong,et al."Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption".BMC GENETICS 16.1(2015):61. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。