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Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
文献类型：期刊论文
| 作者 | He, Meian; Xu, Min; Zhang, Ben; Liang, Jun; Chen, Peng; Lee, Jong-Young; Johnson, Todd A.; Li, Huaixing（黎怀星）; Yang, Xiaobo; Dai, Juncheng |
| 刊名 | HUMAN MOLECULAR GENETICS
 |
| 出版日期 | 2015 |
| 卷号 | 24期号:6页码:17910-1800 |
| 通讯作者 | He, MA (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China. |
| 英文摘要 | Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P<5x10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7single-nucleotide polymorphisms are with low frequency (MAF <5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | CORONARY-ARTERY-DISEASE ; GENOTYPE IMPUTATION ; BIOLOGICAL PATHWAYS ; GENETIC-VARIANTS ; CANCER ; RISK ; PHOSPHOLIPIDS ; MUTATIONS ; PTPN11 ; GROWTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350144200023 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/178]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | He, Meian,Xu, Min,Zhang, Ben,et al. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci[J]. HUMAN MOLECULAR GENETICS,2015,24(6):17910-1800. |
| APA | He, Meian.,Xu, Min.,Zhang, Ben.,Liang, Jun.,Chen, Peng.,...&Qi, Lu.(2015).Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.HUMAN MOLECULAR GENETICS,24(6),17910-1800. |
| MLA | He, Meian,et al."Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci".HUMAN MOLECULAR GENETICS 24.6(2015):17910-1800. |
入库方式： OAI收割
来源：上海营养与健康研究所
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