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Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension
文献类型：期刊论文
| 作者 | Lu, Xiangfeng; Wang, Laiyuan; Lin, Xu（林旭） ; Huang, Jianfeng; Gu, C. Charles; He, Meian; Shen, Hongbing; He, Jiang; Zhu, Jingwen; Li, Huaixing（黎怀星）
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| 刊名 | HUMAN MOLECULAR GENETICS
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| 出版日期 | 2015 |
| 卷号 | 24期号:3页码:865-874 |
| 通讯作者 | Gu, DF (reprint author), Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China. |
| 英文摘要 | Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 x 10(-8)) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 x 10(-3) to 5.16 x 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | GENE-CENTRIC ARRAY ; METABOLIC SYNDROME ; PREVALENCE ; MUTATIONS ; METAANALYSIS ; EXPRESSION ; AWARENESS ; GENOTYPES ; VARIANTS ; ARTERIES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350137900021 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/179]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Lu, Xiangfeng,Wang, Laiyuan,Lin, Xu,et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension[J]. HUMAN MOLECULAR GENETICS,2015,24(3):865-874. |
| APA | Lu, Xiangfeng.,Wang, Laiyuan.,Lin, Xu.,Huang, Jianfeng.,Gu, C. Charles.,...&Gu, Dongfeng.(2015).Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.HUMAN MOLECULAR GENETICS,24(3),865-874. |
| MLA | Lu, Xiangfeng,et al."Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension".HUMAN MOLECULAR GENETICS 24.3(2015):865-874. |
入库方式： OAI收割
来源：上海营养与健康研究所
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