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FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
文献类型:期刊论文
作者 | Qi, Qibin; Kilpelainen, Tuomas O.; Downer, Mary K.; Tanaka, Toshiko; Smith, Caren E.; Sluijs, Ivonne; Sonestedtl, Emily; Chull, Audrey Y.; Renstrom, Frida; Lin, Xiaochen |
刊名 | HUMAN MOLECULAR GENETICS |
出版日期 | 2014 |
卷号 | 23期号:25页码:6961-6972 |
通讯作者 | Qi, L (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA. |
英文摘要 | FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BM I. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 x 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 x 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 x 10(-16)), and relative weak associations with lower total energy intake (-6.4 [- 10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [- 0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 x 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity. |
类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
研究领域[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
关键词[WOS] | OBESITY-ASSOCIATED GENE ; TIME PHYSICAL-ACTIVITY ; FAT MASS ; ENERGY-INTAKE ; FOOD-INTAKE ; METABOLIC-RATE ; ASSOCIATION ; CHILDREN ; RS9939609 ; GENOTYPE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000347923000023 |
公开日期 | 2015-12-24 |
版本 | 出版稿 |
源URL | [http://202.127.25.144/handle/331004/180] |
专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
推荐引用方式 GB/T 7714 | Qi, Qibin,Kilpelainen, Tuomas O.,Downer, Mary K.,et al. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals[J]. HUMAN MOLECULAR GENETICS,2014,23(25):6961-6972. |
APA | Qi, Qibin.,Kilpelainen, Tuomas O..,Downer, Mary K..,Tanaka, Toshiko.,Smith, Caren E..,...&Qi, Lu.(2014).FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.HUMAN MOLECULAR GENETICS,23(25),6961-6972. |
MLA | Qi, Qibin,et al."FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals".HUMAN MOLECULAR GENETICS 23.25(2014):6961-6972. |
入库方式: OAI收割
来源:上海营养与健康研究所
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