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Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
文献类型：期刊论文
| 作者 | Wen, Wanqing; Zheng, Wei; Okada, Yukinori; Takeuchi, Fumihiko; Tabara, Yasuharu; Hwang, Joo-Yeon; Dorajoo, Rajkumar; Li, Huaixing（黎怀星）; Tsai, Fuu-Jen; Yang, Xiaobo |
| 刊名 | HUMAN MOLECULAR GENETICS
 |
| 出版日期 | 2014 |
| 卷号 | 23期号:20页码:5492-5504 |
| 通讯作者 | Shu, XO (reprint author), Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, 2525 West End Ave,Suite 600 IMPH, Nashville, TN 37203 USA. |
| 英文摘要 | Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and similar to 2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 x 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 x 10(-11); rs12229654, P = 4.56 x 10(-9)), ITIH4 (rs2535633, P = 1.77 x 10(-18)) and NT5C2 (rs11191580, P = 3.83 x 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 x 10(-8)) and an additional 14 at P < 1.0 x 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | CORONARY-ARTERY-DISEASE ; COMMON VARIANTS ; BLOOD-PRESSURE ; JAPANESE POPULATION ; GENETIC-VARIANTS ; SUSCEPTIBILITY LOCI ; DRINKING BEHAVIOR ; ADULT OBESITY ; QT INTERVAL ; RISK LOCI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343202400016 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/182]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Wen, Wanqing,Zheng, Wei,Okada, Yukinori,et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index[J]. HUMAN MOLECULAR GENETICS,2014,23(20):5492-5504. |
| APA | Wen, Wanqing.,Zheng, Wei.,Okada, Yukinori.,Takeuchi, Fumihiko.,Tabara, Yasuharu.,...&Tanaka, Toshihiro.(2014).Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.HUMAN MOLECULAR GENETICS,23(20),5492-5504. |
| MLA | Wen, Wanqing,et al."Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index".HUMAN MOLECULAR GENETICS 23.20(2014):5492-5504. |
入库方式： OAI收割
来源：上海营养与健康研究所
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