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Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians
文献类型：期刊论文
| 作者 | Chen, Peng; Takeuchi, Fumihiko; Lee, Jong-Young; Li, Huaixing（黎怀星）; Wu, Jer-Yuarn; Liang, Jun; Long, Jirong; Tabara, Yasuharu; Goodarzi, Mark O.; Pereira, Mark A. |
| 刊名 | DIABETES
 |
| 出版日期 | 2014 |
| 卷号 | 63期号:7页码:2551-2562 |
| 通讯作者 | Tai, ES (reprint author), Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore. |
| 英文摘要 | Glycated hemoglobin A(1c) (HbA(1c)) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA(1c) in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 x 10(-23)], HBS1L/MYB [8.5 x 10(-15)], MYO9B [9.0 x 10(-12)], and CYBA [1.1 x 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA(1c). Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (<7.0 mmol/L) but elevated HbA(1c) (>= 6.5%), 36.1% had HbA(1c) <6.5% after adjustment for these six variants. Our East Asian GWAS meta-analysis has identified novel variants associated with HbA(1c) as well as demonstrated that the effects of known variants are largely transferable across ethnic groups. Variants affecting erythrocyte parameters rather than glucose metabolism may be relevant to the use of HbA(1c) for diagnosing diabetes in these populations. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | WIDE ASSOCIATION ; CELIAC-DISEASE ; METABOLIC SYNDROME ; GENETIC-VARIATION ; OXIDATIVE STRESS ; COMMON VARIANTS ; IRON-DEFICIENCY ; DIABETES RISK ; CELL TRAITS ; METAANALYSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337918200042 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/184]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Chen, Peng,Takeuchi, Fumihiko,Lee, Jong-Young,et al. Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians[J]. DIABETES,2014,63(7):2551-2562. |
| APA | Chen, Peng.,Takeuchi, Fumihiko.,Lee, Jong-Young.,Li, Huaixing.,Wu, Jer-Yuarn.,...&Tai, E-Shyong.(2014).Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians.DIABETES,63(7),2551-2562. |
| MLA | Chen, Peng,et al."Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians".DIABETES 63.7(2014):2551-2562. |
入库方式： OAI收割
来源：上海营养与健康研究所
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