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Elevated Plasma Retinol-Binding Protein 4 Is Associated with Increased Risk of Type 2 Diabetes in Middle-Aged and Elderly Chinese Adults
文献类型：期刊论文
| 作者 | Sun, Liang（孙亮）; Qi, Qibin; Zong, Geng; Ye, Xingwang; Li, Huaixing（黎怀星）; Liu, Xin; Zheng, He; Hu, Frank B.; Liu, Yong（刘勇） ; Lin, Xu（林旭）
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| 刊名 | JOURNAL OF NUTRITION
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| 出版日期 | 2014 |
| 卷号 | 144期号:5页码:722-728 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | The association between circulating retinol-binding protein 4 (RBP4) and risk of type 2 diabetes has been inconsistent in cross-sectional studies, but prospective evidence is limited. We aimed to investigate whether plasma RBP4 is associated with future development of type 2 diabetes and whether the association could be explained by iron or other risk factors. A total of 2091 Chinese adults aged 50-70 y were followed up for 6 y. Baseline dietary intakes and fasting plasma RBP4, ferritin, adiponectin, C-reactive protein (CRP), gamma-glutamyltransferase, creatinine, and erythrocyte fatty acids were determined. Self-reported doctor-diagnosed diabetes, or usage of antidiabetic agents, or fasting plasma glucose concentration at the follow-up visit >= 7.0 mmol/L was defined as an incident diabetes case. Plasma RBP4 concentration was significantly associated with dietary heme iron intake, plasma ferritin concentration, and other established risk factors. After multivariate adjustment for demographic and lifestyle variables, relative risk (RR) for type 2 diabetes when the extreme quartiles of RBP4 were compared was 1.75 (95% Cl: 1.30, 2.37; P-trend <0.001). This association remained significant when the extreme quartiles were compared (RR = 1.48; 95% Cl: 1.06, 2.05; P-trend = 0.036) after further controlling for ferritin and dietary factors, as well as other risk factors, including body mass index, adiponectin, CRP, lipids, liver and kidney function, insulin resistance, and hypertension. A threshold effect of RBP4 concentrations on incident diabetes was suggested by restricted quadratic spline analysis (P = 0.026 for nonlinearity). Our study indicates that plasma RBP4 is independently associated With the 6-y risk of developing type 2 diabetes. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | VITAMIN-A-DEFICIENCY ; FATTY LIVER-DISEASE ; DE-NOVO LIPOGENESIS ; METABOLIC SYNDROME ; INSULIN-RESISTANCE ; RETINOL-BINDING-PROTEIN-4 LEVELS ; TRANSPORT PROTEIN ; IRON-DEFICIENCY ; OLDER CHINESE ; FOLLOW-UP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334970700021 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/186]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Liang,Qi, Qibin,Zong, Geng,et al. Elevated Plasma Retinol-Binding Protein 4 Is Associated with Increased Risk of Type 2 Diabetes in Middle-Aged and Elderly Chinese Adults[J]. JOURNAL OF NUTRITION,2014,144(5):722-728. |
| APA | Sun, Liang.,Qi, Qibin.,Zong, Geng.,Ye, Xingwang.,Li, Huaixing.,...&Lin, Xu.(2014).Elevated Plasma Retinol-Binding Protein 4 Is Associated with Increased Risk of Type 2 Diabetes in Middle-Aged and Elderly Chinese Adults.JOURNAL OF NUTRITION,144(5),722-728. |
| MLA | Sun, Liang,et al."Elevated Plasma Retinol-Binding Protein 4 Is Associated with Increased Risk of Type 2 Diabetes in Middle-Aged and Elderly Chinese Adults".JOURNAL OF NUTRITION 144.5(2014):722-728. |
入库方式： OAI收割
来源：上海营养与健康研究所
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