Associations of Genetic Risk Score with Obesity and Related Traits and the Modifying Effect of Physical Activity in a Chinese Han Population
文献类型：期刊论文
| 作者 | Zhu, Jingwen; Loos, Ruth J. F.; Lu, Ling; Zong, Geng; Gan, Wei; Ye, Xingwang; Sun, Liang（孙亮）; Li, Huaixing（黎怀星）; Lin, Xu（林旭）
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| 刊名 | PLOS ONE
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| 出版日期 | 2014 |
| 卷号 | 9期号:3页码:e91442 |
| 通讯作者 | Li, HX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | Background/Objectives: Recent large-scale genome-wide association studies have identified multiple loci robustly associated with BMI, predominantly in European ancestry (EA) populations. However, associations of these loci with obesity and related traits have not been well described in Chinese Hans. This study aimed to investigate whether BMI-associated loci are, individually and collectively, associated with adiposity-related traits and obesity in Chinese Hans and whether these associations are modified by physical activity (PA). Subjects/Methods: We genotyped 28 BMI-associated single nucleotide polymorphisms (SNPs) in a population-based cohort including 2,894 unrelated Han Chinese. Genetic risk score (GRS), EA and East Asian ancestry (EAA) GRSs were calculated by adding BMI-increasing alleles based on all, EA and EAA identified SNPs, respectively. Interactions of GRS and PA were examined by including the interaction-term in the regression model. Results: Individually, 26 of 28 SNPs showed directionally consistent effects on BMI, and associations of four loci (TMEM18, PCSK1, BDNF and MAP2K5) reached nominal significance(P<0.05). The GRS was associated with increased BMI, trunk fat and body fat percentages; and increased risk of obesity and overweight (all P<0.05). Effect sizes (0.11 vs. 0.17 kg/m(2)) and explained variance (0.90% vs. 1.45%) of GRS for BMI tended to be lower in Chinese Hans than in Europeans. The EA GRS and EAA GRS were associated with 0.11 and 0.13 kg/m(2) higher BMI, respectively. In addition, we found that PA attenuated the effect of the GRS on BMI (P-interaction = 0.022). Conclusions: Our observations suggest that the combined effect of obesity-susceptibility loci on BMI tended to be lower in Han Chinese than in EA. The overall, EA and EAA GRSs exert similar effects on adiposity traits. Genetic predisposition to increased BMI is attenuated by PA in this population of Han Chinese. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | BODY-MASS INDEX ; GENOME-WIDE ASSOCIATION ; SINGLE NUCLEOTIDE POLYMORPHISMS ; FTO RS9939609 POLYMORPHISM ; COMMON VARIANTS ; LOCI ; FAT ; PREDISPOSITION ; CHILDHOOD ; CHILDREN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000332851300085 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/187]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhu, Jingwen,Loos, Ruth J. F.,Lu, Ling,et al. Associations of Genetic Risk Score with Obesity and Related Traits and the Modifying Effect of Physical Activity in a Chinese Han Population[J]. PLOS ONE,2014,9(3):e91442. |
| APA | Zhu, Jingwen.,Loos, Ruth J. F..,Lu, Ling.,Zong, Geng.,Gan, Wei.,...&Lin, Xu.(2014).Associations of Genetic Risk Score with Obesity and Related Traits and the Modifying Effect of Physical Activity in a Chinese Han Population.PLOS ONE,9(3),e91442. |
| MLA | Zhu, Jingwen,et al."Associations of Genetic Risk Score with Obesity and Related Traits and the Modifying Effect of Physical Activity in a Chinese Han Population".PLOS ONE 9.3(2014):e91442. |
入库方式： OAI收割
来源：上海营养与健康研究所
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