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A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2
文献类型：期刊论文
| 作者 | Wu, Ying; Gao, He; Li, Huaixing（黎怀星）; Tabara, Yasuharu; Nakatochi, Masahiro; Chiu, Yen-Feng; Park, Eun Jung; Wen, Wanqing; Adair, Linda S.; Borja, Judith B. |
| 刊名 | HUMAN MOLECULAR GENETICS
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| 出版日期 | 2014 |
| 卷号 | 23期号:4页码:1108-1119 |
| 通讯作者 | Mohlke, KL (reprint author), Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA. |
| 英文摘要 | Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P 3.0 10(14)) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P 1.2 10(7)). Of the adiponectin-associated loci previously described, we confirmed the association at CDH13 (P 6.8 10(165)), ADIPOQ (P 1.8 10(22)), PEPD (P 3.6 10(12)), CMIP (P 2.1 10(10)), ZNF664 (P 2.3 10(7)) and GPR109A (P 7.4 10(6)). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (P-initial 0.020; P-conditional 7.0 10(7)). We further confirmed the independence of two pairs of closely located loci (2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P 3.3 10(4)), high density lipoprotein cholesterol (HDL-C, P 4.9 10(4)) and body mass index (BMI)-adjusted waisthip ratio (P 9.8 10(3)). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | DIABETES SUSCEPTIBILITY LOCI ; CARDIOVASCULAR RISK-FACTORS ; BODY-FAT DISTRIBUTION ; PLASMA ADIPONECTIN ; INSULIN SENSITIVITY ; SERUM ADIPONECTIN ; COMMON VARIANTS ; MENDELIAN RANDOMIZATION ; GENETIC ARCHITECTURE ; JAPANESE POPULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330842100023 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/188]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Wu, Ying,Gao, He,Li, Huaixing,et al. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2[J]. HUMAN MOLECULAR GENETICS,2014,23(4):1108-1119. |
| APA | Wu, Ying.,Gao, He.,Li, Huaixing.,Tabara, Yasuharu.,Nakatochi, Masahiro.,...&Tai, E. Shyong.(2014).A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.HUMAN MOLECULAR GENETICS,23(4),1108-1119. |
| MLA | Wu, Ying,et al."A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2".HUMAN MOLECULAR GENETICS 23.4(2014):1108-1119. |
入库方式： OAI收割
来源：上海营养与健康研究所
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