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A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population
文献类型：期刊论文
| 作者 | Zhou, Li; He, Meian; Mo, Zengnan; Wu, Chen; Yang, Handong; Yu, Dianke; Yang, Xiaobo; Zhang, Xiaomin; Wang, Yiqin; Sun, Jielin |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:12页码:e82420 |
| 通讯作者 | Mo, ZN (reprint author), Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning, Guangxi, Peoples R China. |
| 英文摘要 | Plasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been identified primarily in European populations. In order to identify genetic markers for lipid levels in a Chinese population and analyze the heterogeneity between Europeans and Asians, especially Chinese, we performed a meta-analysis of two genome wide association studies on four common lipid traits including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) in a Han Chinese population totaling 3,451 healthy subjects. Replication was performed in an additional 8,830 subjects of Han Chinese ethnicity. We replicated eight loci associated with lipid levels previously reported in a European population. The loci genome wide significantly associated with TC were near DOCK7, HMGCR and ABO; those genome wide significantly associated with TG were near APOA1/C3/A4/A5 and LPL; those genome wide significantly associated with LDL were near HMGCR, ABO and TOMM40; and those genome wide significantly associated with HDL were near LPL, LIPC and CETP. In addition, an additive genotype score of eight SNPs representing the eight loci that were found to be associated with lipid levels was associated with higher TC, TG and LDL levels (P = 5.52x10(-16), 1.38x10(-6) and 5.59x10(-9), respectively). These findings suggest the cumulative effects of multiple genetic loci on plasma lipid levels. Comparisons with previous GWAS of lipids highlight heterogeneity in allele frequency and in effect size for some loci between Chinese and European populations. The results from our GWAS provided comprehensive and convincing evidence of the genetic determinants of plasma lipid levels in a Chinese population. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | CORONARY-ARTERY-DISEASE ; RISK ; LOCI ; CHOLESTEROL ; TRIGLYCERIDES ; VISUALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329194700006 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/190]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Li,He, Meian,Mo, Zengnan,et al. A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population[J]. PLOS ONE,2013,8(12):e82420. |
| APA | Zhou, Li.,He, Meian.,Mo, Zengnan.,Wu, Chen.,Yang, Handong.,...&Wu, Tangchun.(2013).A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population.PLOS ONE,8(12),e82420. |
| MLA | Zhou, Li,et al."A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population".PLOS ONE 8.12(2013):e82420. |
入库方式： OAI收割
来源：上海营养与健康研究所
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