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Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci
文献类型：期刊论文
| 作者 | Kelly, Tanika N.; Takeuchi, Fumihiko; Tabara, Yasuharu; Edwards, Todd L.; Kim, Young Jin; Chen, Peng; Li, Huaixing（黎怀星）; Wu, Ying; Yang, Chi-Fan; Zhang, Yonghong |
| 刊名 | HYPERTENSION
 |
| 出版日期 | 2013 |
| 卷号 | 62期号:5页码:853-859 |
| 关键词 | blood pressure genetics genome-wide association study hypertension meta-analysis polymorphism single nucleotide |
| 通讯作者 | Kelly, TN (reprint author), Tulane Univ, Dept Epidemiol, 1440 Canal St,Suite 2000, New Orleans, LA 70112 USA. |
| 英文摘要 | We conducted a genome-wide association study meta-analysis of mean arterial pressure and pulse pressure among 26600 East Asian participants (stage 1) followed by replication study of up to 28783 participants (stage 2). For novel loci, statistical significance was determined by a P<5.0x10(-8) in joint analysis of stage 1 and stage 2 data. For loci reported by the previous mean arterial and pulse pressure genome-wide association study meta-analysis in Europeans, evidence of transethnic replication was determined by consistency in effect direction and a Bonferroni-corrected P<1.4x10(-3). No novel loci were identified by the current study. Five independent mean arterial pressure variants demonstrated robust evidence for transethnic replication including rs17249754 at ATP2B1 (P=7.5x10(-15)), rs2681492 at ATP2B1 (P=3.4x10(-7)), rs11191593 at NT5C2 (1.1x10(-6)), rs3824755 at CYP17A1 (P=1.2x10(-6)), and rs13149993 at FGF5 (P=2.4x10(-4)). Two additional variants showed suggestive evidence of transethnic replication (consistency in effect direction and P<0.05), including rs319690 at MAP4 (P=0.014) and rs1173771 at NPR3 (P=0.018). For pulse pressure, robust evidence of replication was identified for 2 independent variants, including rs17249754 at ATP2B1 (P=1.2x10(-5)) and rs11191593 at NT5C2 (P=1.1x10(-3)), with suggestive evidence of replication among an additional 2 variants including rs3824755 at CYP17A1 (P=6.1x10(-3)) and rs2681492 at ATP2B1 (P=9.0x10(-3)). Replicated variants demonstrated consistency in effect sizes between East Asian and European samples, with effect size differences ranging from 0.03 to 0.24 mmHg for mean arterial pressure and from 0.03 to 0.21 mmHg for pulse pressure. In conclusion, we present the first evidence of transethnic replication of several mean arterial and pulse pressure loci in an East Asian population. |
| 类目[WOS] | Peripheral Vascular Disease |
| 研究领域[WOS] | Cardiovascular System & Cardiology |
| 关键词[WOS] | CORONARY-HEART-DISEASE ; BLOOD-PRESSURE ; GLOBAL BURDEN ; RISK ; HYPERTENSION ; POPULATION ; VARIANTS ; HERITABILITY ; IMPUTATION ; GENOTYPES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330110000021 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/191]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Kelly, Tanika N.,Takeuchi, Fumihiko,Tabara, Yasuharu,et al. Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci[J]. HYPERTENSION,2013,62(5):853-859. |
| APA | Kelly, Tanika N..,Takeuchi, Fumihiko.,Tabara, Yasuharu.,Edwards, Todd L..,Kim, Young Jin.,...&He, Jiang.(2013).Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci.HYPERTENSION,62(5),853-859. |
| MLA | Kelly, Tanika N.,et al."Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci".HYPERTENSION 62.5(2013):853-859. |
入库方式： OAI收割
来源：上海营养与健康研究所
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