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Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese
文献类型：期刊论文
| 作者 | Zong, Geng; Zhu, Jingwen; Sun, Liang（孙亮）; Ye, Xingwang; Lu, Ling; Jin, Qianlu（金倩璐）; Zheng, He; Yu, Zhijie; Zhu, Zhenni; Li, Huaixing（黎怀星） |
| 刊名 | AMERICAN JOURNAL OF CLINICAL NUTRITION
 |
| 出版日期 | 2013 |
| 卷号 | 98期号:2页码:319-326 |
| 通讯作者 | Sun, Q (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. |
| 英文摘要 | Background: Experimental studies suggest that elevated de novo lipogenesis (DNL) might be involved in the pathogenesis of metabolic disorders. Few prospective studies have been conducted, especially among populations with a high carbohydrate intake, to determine whether DNL fatty acids are associated with the risk of the metabolic syndrome (MetS). Objective: We aimed to investigate associations of erythrocyte fatty acids in the DNL pathway-including myristic acid (14:0), palmitic acid (16:0), palmitoleic acid (16:1n-7), hexadecenoic acid (16:1n-9), stearic acid (18:0), vaccenic acid (18:1n-7), and oleic acid (18: 1n-9)-with the risk of MetS in a Chinese population with an average carbohydrate intake of >60% of energy. Design: A total of 1176 free-living Chinese men and women aged 50-70 y from Beijing and Shanghai were included in our analysis, giving rise to 412 incident MetS cases during 6 y of follow-up. Erythrocyte fatty acids and metabolic traits were measured in these participants. Results: Erythrocyte fatty acids in the DNL pathway were correlated with a high ratio of carbohydrate-to-fat intake, less favorable lipid profiles, and elevated liver enzymes at baseline. In comparison with the lowest quartile, RRs (95% CIs) of MetS in the highest quartile were 1.30 (1.04, 1.62; P-trend = 0.007) for 16:1n-7, 1.48 (1.17, 1.86; P-trend < 0.001) for 16:1n-9, 1.26 (1.01, 1.56; P-trend = 0.06) for 18:1n-7, and 1.51 (1.19, 1.92; P-trend < 0.001) for 18:1n-9 after multivariate adjustment for lifestyle factors and body mass index. Moreover, 16:0 and 16:1n-7 were associated with an elevated risk of diabetes. Conclusion: Our findings suggest that fatty acids in the DNL pathway are independently associated with an elevated risk of metabolic disorders. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | COA DESATURASE ACTIVITY ; CORONARY-HEART-DISEASE ; SERUM-LIPIDS ; INSULIN SENSITIVITY ; LOW-CARBOHYDRATE ; PLASMA ; MEN ; NUTRITION ; BLOOD ; PHOSPHOLIPIDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322287400009 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/194]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zong, Geng,Zhu, Jingwen,Sun, Liang,et al. Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2013,98(2):319-326. |
| APA | Zong, Geng.,Zhu, Jingwen.,Sun, Liang.,Ye, Xingwang.,Lu, Ling.,...&Lin, Xu.(2013).Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese.AMERICAN JOURNAL OF CLINICAL NUTRITION,98(2),319-326. |
| MLA | Zong, Geng,et al."Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese".AMERICAN JOURNAL OF CLINICAL NUTRITION 98.2(2013):319-326. |
入库方式： OAI收割
来源：上海营养与健康研究所
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