Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome
文献类型：期刊论文
| 作者 | Zong, Geng; Demark-Wahnefried, Wendy; Wu, Hongyu; Lin, Xu（林旭）
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| 刊名 | EUROPEAN JOURNAL OF NUTRITION
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| 出版日期 | 2013 |
| 卷号 | 52期号:5页码:1547-1551 |
| 关键词 | Flaxseed PUFA Cytokines Metabolic syndrome |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS). This study was a secondary analysis of a 12-week, randomized, parallel-group trial in participants screened for MetS. The analysis included only those with 2 or more components of MetS before receiving either lifestyle counseling (LC, n = 90) or LC + 30 g/day flaxseed supplementation (LCF, n = 83). Compared to the LC group, those in the LCF group experienced significant increases in total erythrocyte n-3 PUFAs, alpha-linolenic acid, eicosapentenoic acid, and docosapentenoic acid (all P < 0.001), while total n-6 PUFAs (P < 0.05) and n-6/n-3 ratio decreased (P < 0.001). Arachidonic acid increased significantly in the LC group (P < 0.001), and serum high-sensitivity C-reactive protein, interleukin-18, soluble intracellular adhesion molecular-1, E-selectin, and plasminogen activator inhibitor-1 declined significantly in both groups (all P < 0.05), but no between-group differences were observed. There was no significant change in serum interleukin-6, tumor necrosis factor-alpha, soluble vascular adhesion molecular-1, monocyte chemoattractant protein-1, and oxidized low-density lipoprotein in either group. These data suggest that flaxseed supplementation increases erythrocyte n-3 PUFAs, decreases n-6 PUFAs and n-6/n-3 ratio in participants with risk factors of MetS, but has no additional benefits beyond the lifestyle consulting for the multiple biomarkers tested in the current study. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | ALPHA-LINOLENIC-ACID ; CARDIOVASCULAR-DISEASE ; DOUBLE-BLIND ; MARKERS ; TRIAL ; WOMEN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322008000015 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/195]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zong, Geng,Demark-Wahnefried, Wendy,Wu, Hongyu,et al. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome[J]. EUROPEAN JOURNAL OF NUTRITION,2013,52(5):1547-1551. |
| APA | Zong, Geng,Demark-Wahnefried, Wendy,Wu, Hongyu,&Lin, Xu.(2013).Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome.EUROPEAN JOURNAL OF NUTRITION,52(5),1547-1551. |
| MLA | Zong, Geng,et al."Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome".EUROPEAN JOURNAL OF NUTRITION 52.5(2013):1547-1551. |
入库方式： OAI收割
来源：上海营养与健康研究所
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