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A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans
文献类型：期刊论文
| 作者 | Li, Huaixing（黎怀星）; Gan, Wei; Lu, Ling; Dong, Xiao; Han, Xueyao; Hu, Cheng; Yang, Zhen; Sun, Liang（孙亮）; Bao, Wei; Li, Pengtao |
| 刊名 | DIABETES
 |
| 出版日期 | 2013 |
| 卷号 | 62期号:1页码:291-298 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China. |
| 英文摘要 | Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a genome-wide association study and a replication study in Chinese Hans comprising 8,569 T2D case subjects and 8,923 control subjects in total, from which 10 single nucleotide polymorphisms were selected for further follow-up in a de novo replication sample of 3,410 T2D case and 3,412 control subjects and an in silico replication sample of 6,952 T2D case and 11,865 control subjects. Besides confirming seven established T2D loci (CDKAL1, CDKN2A/B, KCNQ1, CDC123, GLIS3, HNF1B, and DUSP9) at genome-wide significance, we identified two novel T2D loci, including G-protein-coupled receptor kinase 5 (GRK5) (rs10886471: P = 7.1 x 10(-9)) and RASGRP1 (rs7403531: P = 3.9 x 10-9), of which the association signal at GRK5 seems to be specific to East Asians. In nondiabetic individuals, the T2D risk-increasing allele of RASGRP1-rs7403531 was also associated with higher HbA(1c), and lower homeostasis model assessment of beta-cell function (P = 0.03 and 0.0209, respectively), whereas the T2D risk-increasing allele of GRK5-rs10886471 was also associated with higher fasting insulin (P = 0.0169) but not with fasting glucose. Our findings not only provide new insights into the pathophysiology of T2D, but may also shed light on the ethnic differences in T2D susceptibility. Diabetes 62:291-298, 2013 |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | PANCREATIC BETA-CELL ; SUSCEPTIBILITY LOCI ; RECEPTOR ; POPULATION ; PHOSPHORYLATION ; INFLAMMATION ; VARIANTS ; GLUCOSE ; DIFFERENTIATION ; INTERNALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312824700038 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/196]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Li, Huaixing,Gan, Wei,Lu, Ling,et al. A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans[J]. DIABETES,2013,62(1):291-298. |
| APA | Li, Huaixing.,Gan, Wei.,Lu, Ling.,Dong, Xiao.,Han, Xueyao.,...&Lin, Xu.(2013).A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans.DIABETES,62(1),291-298. |
| MLA | Li, Huaixing,et al."A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans".DIABETES 62.1(2013):291-298. |
入库方式： OAI收割
来源：上海营养与健康研究所
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