Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults
文献类型：期刊论文
| 作者 | Zhang, Geng; Ding, Hanqing; Chen, Honglei; Ye, Xingwang; Li, Huaixing（黎怀星）; Lin, Xu（林旭） ; Ke, Zunji
|
| 刊名 | JOURNAL OF NUTRITION
 |
| 出版日期 | 2013 |
| 卷号 | 143期号:1页码:53-58 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | Thiamine has been hypothesized to play an important role in mental health; however, few studies have investigated the association between thiamine nutritional status and depression in the general population. Concentrations of free thiamine and its phosphate esters [thiamine monophosphate (TMP) and thiamine diphosphate (TDP)] in erythrocytes were measured by HPLC among 1587 Chinese men and women aged 50-70 y. The presence of depressive symptoms was defined as a Center for Epidemiological Studies Depression Scale score of >= 16. The median erythrocyte concentration (nmol/L) was 3.73 for free thiamine, 3.74 for TMP, and 169 for TDP. The overall prevalence of depressive symptoms was 11.3%. Lower concentrations of all 3 erythrocyte thiamine biomarkers were monotonically associated with a higher prevalence of depressive symptoms: the multivariable adjusted ORs comparing the lowest with the highest quartiles were 2.97 (95% CI = 1.87, 4.72; P-trend < 0.001) for free thiamine, 3.46 (95% CI = 1.99, 6.02; P-trend < 0.001) for TMP, and 1.98 (95% CI = 1.22, 3.21; P-trend = 0.002) for TDP. In conclusion, poorer thiamine nutritional status and higher odds of depressive symptoms were associated among older Chinese adults. This finding should be further investigated in prospective or interventional studies. J. Nutr. 143: 53-58, 2013. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | ERYTHROCYTE TRANSKETOLASE ACTIVITY ; ALZHEIMERS-DISEASE ; ELDERLY-PEOPLE ; DEFICIENCY ; BLOOD ; NEURODEGENERATION ; SUPPLEMENTATION ; PYROPHOSPHATE ; DIPHOSPHATE ; IMPAIRMENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313153500008 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/197]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Geng,Ding, Hanqing,Chen, Honglei,et al. Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults[J]. JOURNAL OF NUTRITION,2013,143(1):53-58. |
| APA | Zhang, Geng.,Ding, Hanqing.,Chen, Honglei.,Ye, Xingwang.,Li, Huaixing.,...&Ke, Zunji.(2013).Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults.JOURNAL OF NUTRITION,143(1),53-58. |
| MLA | Zhang, Geng,et al."Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults".JOURNAL OF NUTRITION 143.1(2013):53-58. |
入库方式： OAI收割
来源：上海营养与健康研究所
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