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Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese
文献类型：期刊论文
| 作者 | Zong, Geng; Ye, Xingwang; Sun, Liang（孙亮）; Li, Huaixing（黎怀星）; Yu, Zhijie; Hu, Frank B.; Sun, Qi; Lin, Xu（林旭）
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| 刊名 | AMERICAN JOURNAL OF CLINICAL NUTRITION
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| 出版日期 | 2012 |
| 卷号 | 96期号:5页码:970-58 |
| 通讯作者 | Sun, Q (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02118 USA. |
| 英文摘要 | Background: Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial. Objective: We aimed to investigate associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population. Design: Erythrocyte fatty acids were measured in a population-based sample of 3107 men and women aged 50-70 y, for whom plasma glucose, insulin, lipid profile, adiponectin, retinol binding protein 4 (RBP-4), plasminogen activator inhibitor type 1, and high-sensitivity C-reactive protein (hsCRP) were measured. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Results: The mean (+/- SD) erythrocyte palmitoleic acid value was 0.41 +/- 0.20% of total fatty acids. Palmitoleic acid was positively correlated with RBP-4 (r = 0.14, P < 0.001) and inversely correlated with adiponectin (r = -0.15, P < 0.001). After multivariable adjustment, palmitoleic acid was strongly associated with MetS and its components. ORs (95% CIs) for comparisons of extreme quartiles of palmitoleic acid were 3.50 (2.66, 4.59) for MetS, 7.88 (5.90, 10.52) for hypertriglyceridemia, 2.13 (1.66, 2.72) for reduced HDL cholesterol, 1.99 (1.60, 2.48) for central obesity, and 1.86 (1.41, 2.44) for elevated blood pressure (all P < 0.001). Further control for adipokines and hsCRP abolished the association of palmitoleic acid with central obesity but not with other MetS components. Conclusion: Erythrocyte palmitoleic acid is associated with an adverse profile of adipokines and inflammatory markers and an increased risk of MetS in this Chinese population. Am J Clin Nutr 2012;96:970-6. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | C-REACTIVE PROTEIN ; FATTY-ACIDS ; ADIPOSE-TISSUE ; SKELETAL-MUSCLE ; SERUM-LIPIDS ; INSULIN SENSITIVITY ; MEN ; DISEASE ; OBESITY ; HUMANS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312949600005 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/198]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zong, Geng,Ye, Xingwang,Sun, Liang,et al. Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2012,96(5):970-58. |
| APA | Zong, Geng.,Ye, Xingwang.,Sun, Liang.,Li, Huaixing.,Yu, Zhijie.,...&Lin, Xu.(2012).Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese.AMERICAN JOURNAL OF CLINICAL NUTRITION,96(5),970-58. |
| MLA | Zong, Geng,et al."Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese".AMERICAN JOURNAL OF CLINICAL NUTRITION 96.5(2012):970-58. |
入库方式： OAI收割
来源：上海营养与健康研究所
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