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Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese

文献类型:期刊论文

作者Zong, Geng; Ye, Xingwang; Sun, Liang(孙亮); Li, Huaixing(黎怀星); Yu, Zhijie; Hu, Frank B.; Sun, Qi; Lin, Xu(林旭)
刊名AMERICAN JOURNAL OF CLINICAL NUTRITION
出版日期2012
卷号96期号:5页码:970-58
通讯作者Sun, Q (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02118 USA.
英文摘要Background: Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial. Objective: We aimed to investigate associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population. Design: Erythrocyte fatty acids were measured in a population-based sample of 3107 men and women aged 50-70 y, for whom plasma glucose, insulin, lipid profile, adiponectin, retinol binding protein 4 (RBP-4), plasminogen activator inhibitor type 1, and high-sensitivity C-reactive protein (hsCRP) were measured. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Results: The mean (+/- SD) erythrocyte palmitoleic acid value was 0.41 +/- 0.20% of total fatty acids. Palmitoleic acid was positively correlated with RBP-4 (r = 0.14, P < 0.001) and inversely correlated with adiponectin (r = -0.15, P < 0.001). After multivariable adjustment, palmitoleic acid was strongly associated with MetS and its components. ORs (95% CIs) for comparisons of extreme quartiles of palmitoleic acid were 3.50 (2.66, 4.59) for MetS, 7.88 (5.90, 10.52) for hypertriglyceridemia, 2.13 (1.66, 2.72) for reduced HDL cholesterol, 1.99 (1.60, 2.48) for central obesity, and 1.86 (1.41, 2.44) for elevated blood pressure (all P < 0.001). Further control for adipokines and hsCRP abolished the association of palmitoleic acid with central obesity but not with other MetS components. Conclusion: Erythrocyte palmitoleic acid is associated with an adverse profile of adipokines and inflammatory markers and an increased risk of MetS in this Chinese population. Am J Clin Nutr 2012;96:970-6.
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]C-REACTIVE PROTEIN ; FATTY-ACIDS ; ADIPOSE-TISSUE ; SKELETAL-MUSCLE ; SERUM-LIPIDS ; INSULIN SENSITIVITY ; MEN ; DISEASE ; OBESITY ; HUMANS
收录类别SCI
语种英语
WOS记录号WOS:000312949600005
公开日期2015-12-24
版本出版稿
源URL[http://202.127.25.144/handle/331004/198]  
专题中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组
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GB/T 7714
Zong, Geng,Ye, Xingwang,Sun, Liang,et al. Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2012,96(5):970-58.
APA Zong, Geng.,Ye, Xingwang.,Sun, Liang.,Li, Huaixing.,Yu, Zhijie.,...&Lin, Xu.(2012).Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese.AMERICAN JOURNAL OF CLINICAL NUTRITION,96(5),970-58.
MLA Zong, Geng,et al."Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese".AMERICAN JOURNAL OF CLINICAL NUTRITION 96.5(2012):970-58.

入库方式: OAI收割

来源:上海营养与健康研究所

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