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Novel biomarkers for pre-diabetes identified by metabolomics
文献类型：期刊论文
| 作者 | Wang-Sattler, Rui; Yu, Zhonghao; Herder, Christian; Messias, Ana C.; Floegel, Anna; He, Ying; Heim, Katharina; Campillos, Monica; Holzapfel, Christina; Thorand, Barbara |
| 刊名 | MOLECULAR SYSTEMS BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 8期号:1页码:615 |
| 关键词 | early diagnostic biomarkers IGT metabolomics prediction T2D |
| 通讯作者 | Wang-Sattler, R (reprint author), Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, D-85764 Munich, Germany. |
| 英文摘要 | Type 2 diabetes (T2D) can be prevented in pre-diabetic individuals with impaired glucose tolerance (IGT). Here, we have used a metabolomics approach to identify candidate biomarkers of pre-diabetes. We quantified 140 metabolites for 4297 fasting serum samples in the population-based Cooperative Health Research in the Region of Augsburg (KORA) cohort. Our study revealed significant metabolic variation in pre-diabetic individuals that are distinct from known diabetes risk indicators, such as glycosylated hemoglobin levels, fasting glucose and insulin. We identified three metabolites (glycine, lysophosphatidylcholine (LPC) (18:2) and acetylcarnitine) that had significantly altered levels in IGT individuals as compared to those with normal glucose tolerance, with P-values ranging from 2.4 x 10(-4) to 2.1 x 10(-13). Lower levels of glycine and LPC were found to be predictors not only for IGT but also for T2D, and were independently confirmed in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort. Using metabolite-protein network analysis, we identified seven T2D-related genes that are associated with these three IGT-specific metabolites by multiple interactions with four enzymes. The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D. Molecular Systems Biology 8: 615; published online 25 September 2012; doi:10.1038/msb.2012.43 |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TYPE-2 DIABETES-MELLITUS ; IMPAIRED GLUCOSE-TOLERANCE ; MUSCLE INSULIN-RESISTANCE ; FATTY-ACID OXIDATION ; KORA S4/F4 COHORT ; LIFE-STYLE ; EPIC-GERMANY ; POPULATION ; RISK ; SENSITIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309465700008 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/200]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Wang-Sattler, Rui,Yu, Zhonghao,Herder, Christian,et al. Novel biomarkers for pre-diabetes identified by metabolomics[J]. MOLECULAR SYSTEMS BIOLOGY,2012,8(1):615. |
| APA | Wang-Sattler, Rui.,Yu, Zhonghao.,Herder, Christian.,Messias, Ana C..,Floegel, Anna.,...&Illig, Thomas.(2012).Novel biomarkers for pre-diabetes identified by metabolomics.MOLECULAR SYSTEMS BIOLOGY,8(1),615. |
| MLA | Wang-Sattler, Rui,et al."Novel biomarkers for pre-diabetes identified by metabolomics".MOLECULAR SYSTEMS BIOLOGY 8.1(2012):615. |
入库方式： OAI收割
来源：上海营养与健康研究所
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