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Associations between Ionomic Profile and Metabolic Abnormalities in Human Population
文献类型：期刊论文
| 作者 | Sun, Liang（孙亮）; Yu, Yu; Huang, Tao; An, Peng; Yu, Danxia; Yu, Zhijie; Li, Huaixing（黎怀星）; Sheng, Hongguang; Cai, Lu; Xue, Jun |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:6页码:e38845 |
| 通讯作者 | Sun, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | Background: Few studies assessed effects of individual and multiple ions simultaneously on metabolic outcomes, due to methodological limitation. Methodology/Principal Findings: By combining advanced ionomics and mutual information, a quantifying measurement for mutual dependence between two random variables, we investigated associations of ion modules/networks with overweight/obesity, metabolic syndrome (MetS) and type 2 diabetes (T2DM) in 976 middle-aged Chinese men and women. Fasting plasma ions were measured by inductively coupled plasma mass spectroscopy. Significant ion modules were selected by mutual information to construct disease related ion networks. Plasma copper and phosphorus always ranked the first two among three specific ion networks associated with overweight/obesity, MetS and T2DM. Comparing the ranking of ion individually and in networks, three patterns were observed (1) "Individual ion," such as potassium and chrome, which tends to work alone; (2) "Module ion," such as iron in T2DM, which tends to act in modules/network; and (3) "odule-individual ion," such as copper in overweight/obesity, which seems to work equivalently in either way. Conclusions: In conclusion, by using the novel approach of the ionomics strategy and the information theory, we observed potential associations of ions individually or as modules/networks with metabolic disorders. Certainly, these findings need to be confirmed in future biological studies. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | OXIDATIVE STRESS ; MUTUAL INFORMATION ; MATHEMATICAL-THEORY ; INSULIN-RESISTANCE ; BIOLOGICAL SAMPLES ; DIABETES-MELLITUS ; FEATURE-SELECTION ; IRON STORES ; VITAMIN-D ; COPPER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000305341900054 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/201]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Liang,Yu, Yu,Huang, Tao,et al. Associations between Ionomic Profile and Metabolic Abnormalities in Human Population[J]. PLOS ONE,2012,7(6):e38845. |
| APA | Sun, Liang.,Yu, Yu.,Huang, Tao.,An, Peng.,Yu, Danxia.,...&Wang, Fudi.(2012).Associations between Ionomic Profile and Metabolic Abnormalities in Human Population.PLOS ONE,7(6),e38845. |
| MLA | Sun, Liang,et al."Associations between Ionomic Profile and Metabolic Abnormalities in Human Population".PLOS ONE 7.6(2012):e38845. |
入库方式： OAI收割
来源：上海营养与健康研究所
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