Erythrocyte n-3 Fatty Acids and Metabolic Syndrome in Middle-Aged and Older Chinese
文献类型：期刊论文
| 作者 | Zhang, Geng; Sun, Qi; Hu, Frank B.; Ye, Xingwang; Yu, Zhijie; Zong, Geng; Li, Huaixing（黎怀星）; Zhou, Yunhua; Lin, Xu（林旭）
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| 刊名 | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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| 出版日期 | 2012 |
| 卷号 | 97期号:6页码:E973-E977 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Context: Few studies examined associations of circulating n-3 fatty acid levels with metabolic syndrome (MetS) among Chinese populations who have low consumption of these fatty acids and high risk of developing MetS. Objective: The objective of the study was to determine associations between erythrocyte n-3 fatty acids and MetS as well as its components among middle-aged and older Chinese men and women. Design and Participants: Erythrocyte levels of docosahexaenoic acid (DHA), docosapentaenoic acid, eicosapentaenoic acid, and alpha-linolenic acid (ALA) were measured by gas chromatography among 2754 participants aged 50-70 yr living in Beijing and Shanghai. MetS was defined using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: After multivariable adjustment, higher levels of DHA, but neither eicosapentaenoic acid nor docosapentaenoic acid, were associated with lower odds of MetS as well as elevated blood pressure and triglycerides. Comparing extreme quartiles of DHA, odds ratios (95% confidence interval) were 0.75 (0.55, 1.01; P for trend = 0.04) for MetS; 0.70 (0.53, 0.92; P for trend = 0.01) for elevated blood pressure; and 0.64 (0.48, 0.87; P for trend = 0.005) for elevated triglycerides. In contrast, ALA concentrations were positively associated with MetS odds (odds ratio 4.06; 95% confidence interval 2.85, 5.80; P for trend <0.001). Conclusions: Higher concentrations of erythrocyte DHA were associated with lower odds of MetS, whereas higher concentrations of ALA were associated with increased odds among middle-aged and older Chinese. These findings warrant replication in other populations. (J Clin Endocrinol Metab 97: E973-E977, 2012) |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | ALPHA-LINOLENIC ACID ; C-REACTIVE PROTEIN ; RISK ; PLASMA ; LIPIDS ; WOMEN ; HEART ; LUNG |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306100800013 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/202]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Geng,Sun, Qi,Hu, Frank B.,et al. Erythrocyte n-3 Fatty Acids and Metabolic Syndrome in Middle-Aged and Older Chinese[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2012,97(6):E973-E977. |
| APA | Zhang, Geng.,Sun, Qi.,Hu, Frank B..,Ye, Xingwang.,Yu, Zhijie.,...&Lin, Xu.(2012).Erythrocyte n-3 Fatty Acids and Metabolic Syndrome in Middle-Aged and Older Chinese.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,97(6),E973-E977. |
| MLA | Zhang, Geng,et al."Erythrocyte n-3 Fatty Acids and Metabolic Syndrome in Middle-Aged and Older Chinese".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97.6(2012):E973-E977. |
入库方式： OAI收割
来源：上海营养与健康研究所
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