Associations of Type 2 Diabetes with Common Variants in PPARD and the Modifying Effect of Vitamin D among Middle-Aged and Elderly Chinese
文献类型：期刊论文
| 作者 | Lu, Ling; Wu, Ying; Qi, Qibin; Liu, Chen; Gan, Wei; Zhu, Jingwen; Li, Huaixing（黎怀星）; Lin, Xu（林旭）
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| 刊名 | PLOS ONE
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| 出版日期 | 2012 |
| 卷号 | 7期号:4页码:e34895 |
| 通讯作者 | Lu, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | Background: Previous studies have identified that variants in peroxisome proliferator-activated receptor PPAR-delta (PPARD), a target gene of vitamin D, were significantly associated with fasting glucose and insulin sensitivity in European populations. This current study sought to determine (1) whether the genetic associations of PPARD variants with type 2 diabetes and its related traits could be replicated in Chinese Han population, and (2) whether the associations would be modified by the effect of vitamin D status. Methods and Findings: We genotyped 9 tag single nucleotide polymorphisms (SNPs) that cover the gene of PPARD (rs2267664, rs6902123, rs3798343, rs2267665, rs2267668, rs2016520, rs2299869, rs1053049, and rs9658056) and tested their associations with type 2 diabetes risk and its related traits, including fasting glucose, insulin and HbA1c in 3,210 Chinese Hans. Among the 9 PPARD tag SNPs, rs6902123 was significantly associated with risk of type 2 diabetes (odds ratio 1.75 [95%CI 1.22-2.53]; P = 0.0025) and combined type 2 diabetes and impaired fasting glucose (IFG) (odds ratio 1.47 [95%CI 1.12-1.92]; P = 0.0054). The minor C allele of rs6902123 was associated with increased levels of fasting glucose (P = 0.0316) and HbA1c (P = 0.0180). In addition, we observed that vitamin D modified the effect of rs6902123 on HbA1c (P for interaction = 0.0347). Conclusions/Significance: Our findings demonstrate that common variants in PPARD contribute to the risk of type 2 diabetes in Chinese Hans, and provided suggestive evidence of interaction between 25(OH) D levels and PPARD-rs6902123 on HbA1c. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | PROLIFERATOR-ACTIVATED-RECEPTOR ; 25-HYDROXYVITAMIN D CONCENTRATION ; SINGLE NUCLEOTIDE POLYMORPHISMS ; DELTA-GENE ; METABOLIC SYNDROME ; RISK-FACTORS ; GLUCOSE ; TARGET ; MEN ; OBESITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000305336600065 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/204]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Lu, Ling,Wu, Ying,Qi, Qibin,et al. Associations of Type 2 Diabetes with Common Variants in PPARD and the Modifying Effect of Vitamin D among Middle-Aged and Elderly Chinese[J]. PLOS ONE,2012,7(4):e34895. |
| APA | Lu, Ling.,Wu, Ying.,Qi, Qibin.,Liu, Chen.,Gan, Wei.,...&Lin, Xu.(2012).Associations of Type 2 Diabetes with Common Variants in PPARD and the Modifying Effect of Vitamin D among Middle-Aged and Elderly Chinese.PLOS ONE,7(4),e34895. |
| MLA | Lu, Ling,et al."Associations of Type 2 Diabetes with Common Variants in PPARD and the Modifying Effect of Vitamin D among Middle-Aged and Elderly Chinese".PLOS ONE 7.4(2012):e34895. |
入库方式： OAI收割
来源：上海营养与健康研究所
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