热门
Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans
文献类型：期刊论文
| 作者 | Lu, Ling; Sheng, Hongguang; Li, Huaixing（黎怀星）; Gan, Wei; Liu, Chen; Zhu, Jingwen; Loos, Ruth J. F.; Lin, Xu（林旭）
|
| 刊名 | HUMAN GENETICS
 |
| 出版日期 | 2012 |
| 卷号 | 131期号:3页码:505-512 |
| 通讯作者 | Li, HX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Recent studies have identified common variants in or near GC, CYP2R1 and NADSYN1/DHCR7 to be associated with 25-hydroxyvitamin D [25(OH)D] levels in European populations. We aimed to examine whether these variants also influence 25(OH)D levels in Chinese. Seven common variants were successfully genotyped and tested for associations with plasma 25(OH)D levels in a population-based cohort of 3,210 Chinese Hans from Beijing and Shanghai. Six common variants at GC (rs4588, rs7041, rs2282679 and rs1155563) and NADSYN1/DHCR7 (rs3829251 and rs1790349) loci were all significantly associated with lower plasma 25(OH)D levels (-0.036 a parts per thousand currency sign beta a parts per thousand currency sign -0.076 per risk-allele, P a parts per thousand currency sign 5.7 x 10(-5)), while CYP2R1-rs2060793 showed a trend toward association with 25(OH)D levels in the Shanghai subpopulation (P = 0.08), but not in the Beijing subpopulation (P = 0.82). Haplotype-based association analyses of the four GC variants showed that only the haplotype that contained all risk-alleles (TACC) was significantly associated with lower plasma 25(OH)D levels (beta = -0.085, P = 2.3 x 10(-9)), while the haplotype containing the risk-alleles of rs4588 and rs2282679 (TATC) was marginally associated with lower 25(OH)D levels (beta = -0.054, P = 0.0562) when compared with GCTA haplotype carrying the four protective alleles. Most notably, conditional analyses showed that only GC-rs4588 and GC-rs2282679 (r (2) = 0.97) remained significantly associated with 25(OH)D concentrations (P a parts per thousand currency sign 1.9 x 10(-5)) after adjusting for the other two SNPs in GC. In conclusion, GC and NADSYN1/DHCR7 loci individually and collectively contribute to variation in plasma vitamin D levels in Chinese Hans. |
| 类目[WOS] | Genetics & Heredity |
| 研究领域[WOS] | Genetics & Heredity |
| 关键词[WOS] | D-BINDING PROTEIN ; GENOME-WIDE ASSOCIATION ; 25-HYDROXYVITAMIN D ; PLASMA-CONCENTRATIONS ; POSTMENOPAUSAL WOMEN ; GENETIC CONTRIBUTION ; D DEFICIENCY ; CANCER RISK ; DBP ; POLYMORPHISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300252700018 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/205]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Lu, Ling,Sheng, Hongguang,Li, Huaixing,et al. Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans[J]. HUMAN GENETICS,2012,131(3):505-512. |
| APA | Lu, Ling.,Sheng, Hongguang.,Li, Huaixing.,Gan, Wei.,Liu, Chen.,...&Lin, Xu.(2012).Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.HUMAN GENETICS,131(3),505-512. |
| MLA | Lu, Ling,et al."Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans".HUMAN GENETICS 131.3(2012):505-512. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。