Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese
文献类型：期刊论文
| 作者 | Sun, Liang（孙亮）; Pan, An; Yu, Zhijie; Li, Huaixing（黎怀星）; Shi, Aizhen; Yu, Danxia; Zhang, Geng; Zong, Geng; Liu, Yong（刘勇） ; Lin, Xu（林旭）
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| 刊名 | PLOS ONE
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| 出版日期 | 2011 |
| 卷号 | 6期号:11页码:e27515 |
| 通讯作者 | Sun, L (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China. |
| 英文摘要 | Objective: Chronic low-grade inflammation and adipokines dysregulation are linked to mechanisms underscoring the pathogenesis of obesity-related metabolic disorders. Little is known about roles of these cytokines on the association between snoring and metabolic syndrome (MetS). We aimed to investigate whether a cluster of cytokines are related to snoring frequency and its association with MetS in apparently healthy Chinese. Methods: Current analyses used a population-based sample including 1059 Shanghai residents aged 35-54 years. Self-reported snoring frequency was classified as never, occasionally and regularly. Fasting plasma glucose, lipid profile, insulin, C-reactive protein, interleukin-6, interleukin-18, lipopolysaccharide binding protein, high-molecular-weight adiponectin and leptin were measured. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: Overweight/obese subjects had significantly higher prevalence of regular snorers than their normal-weight counterparts (34.8% vs. 11.5%, P< 0.001). Regular snoring was associated with unfavorable profile of inflammatory markers and adipokines. However, those associations were abolished after adjustment for body mass index (BMI) or waist circumference. The MetS risk (multivariate-adjusted odds ratio 5.41, 95% confidence interval 3.72-7.88) was substantially higher in regular snorers compared with non-snorers. Controlling for BMI remarkably attenuated the association (2.03, 1.26-3.26), while adjusting for inflammatory markers and adipokines showed little effects. Conclusion: Frequent snoring was associated with an elevated MetS risk independent of lifestyle factors, adiposity, inflammatory markers and adipokines in apparently healthy Chinese. Whether snoring pattern is an economic and noinvasive indicator for screening high-risk persons needs to be addressed prospectively. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | OBSTRUCTIVE SLEEP-APNEA ; C-REACTIVE PROTEIN ; VASCULAR RISK-FACTORS ; INSULIN-RESISTANCE ; BLOOD-PRESSURE ; SERUM LEPTIN ; OBESITY ; ASSOCIATION ; POPULATION ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297555400052 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/207]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Liang,Pan, An,Yu, Zhijie,et al. Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese[J]. PLOS ONE,2011,6(11):e27515. |
| APA | Sun, Liang.,Pan, An.,Yu, Zhijie.,Li, Huaixing.,Shi, Aizhen.,...&Lin, Xu.(2011).Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese.PLOS ONE,6(11),e27515. |
| MLA | Sun, Liang,et al."Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese".PLOS ONE 6.11(2011):e27515. |
入库方式： OAI收割
来源：上海营养与健康研究所
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