Associations of Amylin with Inflammatory Markers and Metabolic Syndrome in Apparently Healthy Chinese
文献类型：期刊论文
| 作者 | Hou, Xinwei; Sun, Liang（孙亮）; Li, Zongmeng; Mou, Haiwei; Yu, Zhijie; Li, Huaixing（黎怀星）; Jiang, Peizhen; Yu, Danxia; Wu, Hongyu; Ye, Xingwang |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:9页码:e24815 |
| 通讯作者 | Hou, XW (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China. |
| 英文摘要 | Background: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans. Therefore, we aimed to evaluate the distribution of circulating amylin and its association with metabolic syndrome (MetS) and explore if this association is influenced by obesity, inflammatory markers or insulin resistance in apparently healthy Chinese. Methods: A population-based sample of 1,011 Chinese men and women aged 35-54 years was employed to measure plasma amylin, inflammatory markers (C-reactive protein [CRP] and interleukin-6 [IL-6]), insulin, glucose and lipid profiles. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: Plasma amylin concentrations were higher in overweight/obese participants than normal-weight counterparts (P<0.001) without sex difference. Circulating amylin was positively associated with CRP, IL-6, BMI, waist circumference, blood pressure, fasting glucose, insulin, amylin/insulin ratio, HOMA-IR, LDL cholesterol and triglycerides, while negatively associated with HDL cholesterol (all P<0.001). After multiple adjustments, the risk of MetS was significantly higher (odds ratio 3.71; 95% confidence interval: 2.53 to 5.46) comparing the highest with the lowest amylin quartile. The association remained significant even further controlling for BMI, inflammatory markers, insulin or HOMA-IR. Conclusions: Our study suggests that amylin is strongly associated with inflammatory markers and MetS. The amylin-MetS association is independent of established risk factors of MetS, including obesity, inflammatory markers and insulin resistance. The causal role of hyperamylinemia in the development of MetS needs to be confirmed prospectively. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ISLET AMYLOID POLYPEPTIDE ; DEPENDENT DIABETES-MELLITUS ; OPTIMAL CUTOFF POINTS ; C-REACTIVE PROTEIN ; BODY-MASS INDEX ; INSULIN-RESISTANCE ; SECRETION ; GLUCOSE ; ADULTS ; PEPTIDE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295041700062 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/209]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Hou, Xinwei,Sun, Liang,Li, Zongmeng,et al. Associations of Amylin with Inflammatory Markers and Metabolic Syndrome in Apparently Healthy Chinese[J]. PLOS ONE,2011,6(9):e24815. |
| APA | Hou, Xinwei.,Sun, Liang.,Li, Zongmeng.,Mou, Haiwei.,Yu, Zhijie.,...&Le, Yingying.(2011).Associations of Amylin with Inflammatory Markers and Metabolic Syndrome in Apparently Healthy Chinese.PLOS ONE,6(9),e24815. |
| MLA | Hou, Xinwei,et al."Associations of Amylin with Inflammatory Markers and Metabolic Syndrome in Apparently Healthy Chinese".PLOS ONE 6.9(2011):e24815. |
入库方式： OAI收割
来源：上海营养与健康研究所
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