Lean Body Mass, Interleukin 18, and Metabolic Syndrome in Apparently Healthy Chinese
文献类型：期刊论文
| 作者 | Sun, Liang（孙亮）; Hu, Frank B.; Yu, Zhijie; Li, Huaixing（黎怀星）; Liu, Huaiyu; Wang, Xiangdong; Yu, Danxia; Wu, Hongyu; Zhang, Geng; Zong, Geng |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:3页码:e18104 |
| 通讯作者 | Sun, L (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China. |
| 英文摘要 | Objective: We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese. Methods: A population-based sample of 1059 Chinese men and women aged 35-54 years was used to measure plasma IL-18, glucose, insulin, lipid profile, inflammatory markers and high-molecular-weight (HMW)-adiponectin. Fat mass index (FMI) and lean mass index (LMI) were measured by dual-energy X-ray absorptiometry. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: Circulating IL-18 was positively correlated with LMI after adjustment for FMI (correlation coefficient = 0.11, P < 0.001). The association with the MetS (odds ratio 3.43, 95% confidence interval 2.01-5.85) was substantially higher in the highest than the lowest quartile of IL-18 after multiple adjustments including body mass index. In the stratified multivariable regression analyses, the positive association between IL-18 and MetS was independent of tertiles of FMI, inflammatory markers and HMW-adiponectin, but significantly interacted with tertile of LMI (P for interaction = 0.010). Conclusion: Elevated plasma IL-18 was associated with higher MetS prevalence in apparently healthy Chinese, independent of traditional risk factors, FMI, inflammatory markers and HMW-adiponectin. More studies are needed to clarify the role of lean mass in IL-18 secretion and its associated cardio-metabolic disorders. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | FAT-FREE MASS ; INSULIN-RESISTANCE ; CIRCULATING IL-18 ; OBESE WOMEN ; WEIGHT-LOSS ; EXPRESSION ; CYTOKINE ; DISEASE ; RISK ; INFLAMMATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288545100068 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/212]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Liang,Hu, Frank B.,Yu, Zhijie,et al. Lean Body Mass, Interleukin 18, and Metabolic Syndrome in Apparently Healthy Chinese[J]. PLOS ONE,2011,6(3):e18104. |
| APA | Sun, Liang.,Hu, Frank B..,Yu, Zhijie.,Li, Huaixing.,Liu, Huaiyu.,...&Lin, Xu.(2011).Lean Body Mass, Interleukin 18, and Metabolic Syndrome in Apparently Healthy Chinese.PLOS ONE,6(3),e18104. |
| MLA | Sun, Liang,et al."Lean Body Mass, Interleukin 18, and Metabolic Syndrome in Apparently Healthy Chinese".PLOS ONE 6.3(2011):e18104. |
入库方式： OAI收割
来源：上海营养与健康研究所
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