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Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese
文献类型：期刊论文
| 作者 | Yu, Danxia; Yu, Zhijie; Sun, Qi; Sun, Liang（孙亮）; Li, Huaixing（黎怀星）; Song, Jun; Mi, Ming; Wu, Hongyu; Lu, Ling; Liu, Chen |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:2页码:e16818 |
| 通讯作者 | Yu, DX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | Background: Little is known regarding the associations between high-molecular-weight (HMW-) adiponectin, leptin and soluble leptin receptor (sOB-R) and metabolic syndrome (MetS) in Chinese. Also few studies elucidate the effects of inflammation and body fat mass on the relations. Methods: Plasma HMW-adiponectin, leptin and sOB-R were measured among 1055 Chinese men and women (35 similar to 54 yrs). Whole body and trunk fat mass were determined by Dual-energy X-ray absorptiometry. MetS was defined by the updated NCEP/ATPIII criterion for Asian-Americans. Results: HMW-adiponectin was inversely associated with MetS in multivariate model including fat mass index (FMI), inflammatory markers, leptin and sOB-R (OR in the highest quartile =0.30, 95%CI 0.18 similar to 0.50, P<.0001). Plasma sOB-R was also inversely associated with MetS independent of body fatness and inflammatory markers, whereas the association was somewhat attenuated after adjusting HMW-adiponectin (OR for the highest quartile =0.78, 95%CI 0.47 similar to 1.32, P = 0.15). In contrast, leptin was associated with increased odds of MetS independent of inflammatory markers, HMW-adiponectin, and sOB-R (OR for the highest quartile =2.64, 95%CI 1.35 similar to 5.18, P = 0.006), although further adjustment for FMI abolished this association. Conclusions: HMW-adiponectin exhibited strong inverse associations with MetS independent of body composition, inflammation, leptin and sOB-R; while the associations of leptin and sOB-R were largely explained by fat mass or HMW-adiponectin, respectively. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | C-REACTIVE PROTEIN ; RISK-FACTORS ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; CARDIOVASCULAR-DISEASE ; OBESITY ; WOMEN ; SENSITIVITY ; HEALTH ; ADIPOCYTOKINES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287369200008 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/213]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Yu, Danxia,Yu, Zhijie,Sun, Qi,et al. Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese[J]. PLOS ONE,2011,6(2):e16818. |
| APA | Yu, Danxia.,Yu, Zhijie.,Sun, Qi.,Sun, Liang.,Li, Huaixing.,...&Lin, Xu.(2011).Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese.PLOS ONE,6(2),e16818. |
| MLA | Yu, Danxia,et al."Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese".PLOS ONE 6.2(2011):e16818. |
入库方式： OAI收割
来源：上海营养与健康研究所
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