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Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans
文献类型：期刊论文
| 作者 | Liu, Chen; Li, Huaixing（黎怀星）; Qi, Qibin; Lu, Ling; Gan, Wei; Loos, Ruth J. F.; Lin, Xu（林旭）
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| 刊名 | JOURNAL OF HYPERTENSION
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| 出版日期 | 2011 |
| 卷号 | 29期号:1页码:70-75 |
| 关键词 | diastolic blood pressure hypertension systolic blood pressure |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Objectives Recent genome-wide association studies have identified a number of variants influencing blood pressure. We aimed to examine whether these associations can be replicated in Chinese. Methods We genotyped eight of these variants (in or near FGF5, CYP17A1, MTHFR, ZNF652, PLCD3, ATP2B1, c10orf107) in a population-based cohort of Chinese Hans (N=3210). Logistics regression and generalized linear analyses were applied to test for association of each variant with hypertension risk and blood pressure (BP), BMI, waistline and high-sensitivity C-reactive protein (hsCRP), respectively. Results Six variants showed directionally consistent association with blood pressure and risk of hypertension, of which four (FGF5, two in CYP17A1, MTHFR) reached significance. The associations were most pronounced for FGF-rs 16998073 [SBP: beta=1.97 mmHg/allele, P=0.0006; DBP: beta=0.95 mmHg/allele, P=0.0008, hypertension: odds ratio (OR) 1.36/allele, P=0.0001]. Effect size of FGF5-rs16998073 on SBP and hypertension were significantly more pronounced in Han Chinese compared to white Europeans. None of these variants was associated with BMI, waistline or hsCRP that are the well established risk factors for hypertension. The genetic risk score, calculated as the sum of BP-increasing alleles of FGF5-rs16998073, CYP17A1-rs11191548, CYP17A1-rs1004467 and MTHFR-rs17367504, was significantly associated with increased SBP (1.16 mmHg/allele, P=9.01E-5), DBP (0.51mmHg/allele, P=4.40E-4) and hypertension risk (OR=1.22/allele, P=2.74E-7). Conclusion Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans, but more studies with larger sample size are required for a definitive conclusion. J Hypertens 29:70-75 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| 类目[WOS] | Peripheral Vascular Disease |
| 研究领域[WOS] | Cardiovascular System & Cardiology |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; C-REACTIVE PROTEIN ; POPULATIONS ; OBESITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285375800013 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/215]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Liu, Chen,Li, Huaixing,Qi, Qibin,et al. Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans[J]. JOURNAL OF HYPERTENSION,2011,29(1):70-75. |
| APA | Liu, Chen.,Li, Huaixing.,Qi, Qibin.,Lu, Ling.,Gan, Wei.,...&Lin, Xu.(2011).Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.JOURNAL OF HYPERTENSION,29(1),70-75. |
| MLA | Liu, Chen,et al."Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans".JOURNAL OF HYPERTENSION 29.1(2011):70-75. |
入库方式： OAI收割
来源：上海营养与健康研究所
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