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Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women
文献类型：期刊论文
| 作者 | Wu, Hongyu; Qi, Qibin; Yu, Zhijie; Sun, Qi; Wang, Jing; Franco, Oscar H.; Sun, Liang（孙亮）; Li, Huaixing（黎怀星）; Liu, Yong（刘勇） ; Hu, Frank B.
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| 刊名 | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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| 出版日期 | 2010 |
| 卷号 | 95期号:9页码:4389-4398 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Objective: The objective was to investigate associations of regional fat depots with adipokines, inflammatory markers, and risk of metabolic syndrome (MetS) in a Chinese population. Design and Methods: Trunk and leg fat mass were determined in a population-based sample of 1150 Chinese (479 men and 671 women) aged 50-70 yr by using whole-body dual-energy x-ray absorptiometry scan. Plasma adiponectin, plasminogen activator inhibitor-1 (PAI-1), retinol-binding protein 4 (RBP4), resistin, C-reactive protein, and IL-6 were measured. The updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans was used to define MetS. Results: Larger body-size adjusted trunk fat mass was significantly associated with lower adiponectin and higher PAI-1, RBP4, C-reactive protein, and IL-6 levels in both genders (P < 0.05). Larger body-size adjusted leg fat mass was significantly associated with higher adiponectin levels in both genders but lower RBP4 and PAI-1 concentrations in men (P < 0.05). Comparing with the lowest body-size adjusted leg fat mass tertile, the odds ratio (95% confidence interval) of MetS in the highest tertile was 0.33 (0.18-0.62; P for trend < 0.001) for men and 0.43 (0.28-0.65; P for trend < 0.001) for women. The association was attenuated with further controlling adipokines and inflammatory markers (P = 0.09 for men and P = 0.004 for women). Conclusion: In contrast to trunk fat, large leg fat appears to have favorable effects on adipokines, inflammatory markers, and MetS risk among Chinese. The opposite associations between regional fat depots and MetS risk may partially mediated by adipokines and inflammatory status. (J Clin Endocrinol Metab 95: 4389-4398, 2010) |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | VISCERAL ADIPOSE-TISSUE ; C-REACTIVE PROTEIN ; BODY-FAT ; INSULIN-RESISTANCE ; CARDIOVASCULAR-DISEASE ; RISK-FACTORS ; VASCULAR-DISEASE ; ELDERLY-WOMEN ; OBESITY ; ADIPONECTIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281640300056 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/219]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Wu, Hongyu,Qi, Qibin,Yu, Zhijie,et al. Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2010,95(9):4389-4398. |
| APA | Wu, Hongyu.,Qi, Qibin.,Yu, Zhijie.,Sun, Qi.,Wang, Jing.,...&Lin, Xu.(2010).Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,95(9),4389-4398. |
| MLA | Wu, Hongyu,et al."Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 95.9(2010):4389-4398. |
入库方式： OAI收割
来源：上海营养与健康研究所
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