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Identification of New Genetic Risk Variants for Type 2 Diabetes
文献类型：期刊论文
| 作者 | Shu, Xiao Ou; Long, Jirong; Cai, Qiuyin; Qi, Lu; Xiang, Yong-Bing; Cho, Yoon Shin; Tai, E. Shyong; Li, Xiangyang; Lin, Xu（林旭） ; Chow, Wong-Ho
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| 刊名 | PLOS GENETICS
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| 出版日期 | 2010 |
| 卷号 | 6期号:9页码:e1001127 |
| 通讯作者 | Shu, XO (reprint author), Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37212 USA. |
| 英文摘要 | Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the Asian Consortium of Diabetes to search for T2D susceptibility markers. From 590,887 SNPs genotyped in 1,019 T2D cases and 1,710 controls selected from Chinese women in Shanghai, we selected the top 2,100 SNPs that were not in linkage disequilibrium (r(2)<0.2) with known T2D loci for in silico replication in three T2D GWAS conducted among European Americans, Koreans, and Singapore Chinese. The 5 most promising SNPs were genotyped in an independent set of 1,645 cases and 1,649 controls from Shanghai, and 4 of them were further genotyped in 1,487 cases and 3,316 controls from 2 additional Chinese studies. Consistent associations across all studies were found for rs1359790 (13q31.1), rs10906115 (10p13), and rs1436955 (15q22.2) with P-values (per allele OR, 95%CI) of 6.49 x 10(-9) (1.15, 1.10-1.20), 1.45 x 10(-8) (1.13, 1.08-1.18), and 7.14 x 10(-7) (1.13, 1.08-1.19), respectively, in combined analyses of 9,794 cases and 14,615 controls. Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS. |
| 类目[WOS] | Genetics & Heredity |
| 研究领域[WOS] | Genetics & Heredity |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; SPROUTY PROTEINS ; SUSCEPTIBILITY ; INFLAMMATION ; LOCI ; PATHOPHYSIOLOGY ; COMPLICATIONS ; REPLICATION ; MELLITUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000282369200033 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/220]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Shu, Xiao Ou,Long, Jirong,Cai, Qiuyin,et al. Identification of New Genetic Risk Variants for Type 2 Diabetes[J]. PLOS GENETICS,2010,6(9):e1001127. |
| APA | Shu, Xiao Ou.,Long, Jirong.,Cai, Qiuyin.,Qi, Lu.,Xiang, Yong-Bing.,...&Hu, Frank B..(2010).Identification of New Genetic Risk Variants for Type 2 Diabetes.PLOS GENETICS,6(9),e1001127. |
| MLA | Shu, Xiao Ou,et al."Identification of New Genetic Risk Variants for Type 2 Diabetes".PLOS GENETICS 6.9(2010):e1001127. |
入库方式： OAI收割
来源：上海营养与健康研究所
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