热门
Meta-analysis of the effects of flaxseed interventions on blood lipids
文献类型：期刊论文
| 作者 | Pan, An; Yu, Danxia; Demark-Wahnefried, Wendy; Franco, Oscar H.; Lin, Xu（林旭）
|
| 刊名 | AMERICAN JOURNAL OF CLINICAL NUTRITION
 |
| 出版日期 | 2009 |
| 卷号 | 90期号:2页码:288-297 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Background: Several clinical trials have investigated the effects of flaxseed and flaxseed-derived products (flaxseed oil or lignans) on blood lipids; however, the findings have been inconsistent. Objective: We aimed to identify and quantify the effectiveness of flaxseed and its derivatives on blood lipid profiles. Design: A comprehensive literature search was performed on the basis of English reports of randomized controlled trials of flaxseed or its derivatives on lipid profiles in adults, which were published from January 1990 to October 2008. Attempts also were made to access unpublished data. Study quality was assessed by using the Jadad score, and a meta-analysis was conducted. Results: Twenty-eight studies were included. Flaxseed interventions reduced total and LDL cholesterol by 0.10 mmol/L (95% CI: -0.20, 0.00 mmol/L) and 0.08 mmol/L (95% CI: -0.16, 0.00 mmol/L), respectively; significant reductions were observed with whole flaxseed (-0.21 and -0.16 mmol/L, respectively) and lignan (-0.28 and -0.16 mmol/L, respectively) supplements but not with flaxseed oil. The cholesterol-lowering effects were more apparent in females (particularly postmenopausal women), individuals with high initial cholesterol concentrations, and studies with higher Jadad scores. No significant changes were found in the concentrations of HDL cholesterol and triglycerides. Conclusions: Flaxseed significantly reduced circulating total and LDL-cholesterol concentrations, but the changes were dependent on the type of intervention, sex, and initial lipid profiles of the subjects. Further studies are needed to determine the efficiency of flaxseed on lipid profiles in men and premenopausal women and to explore its potential benefits on other cardiometabolic risk factors and prevention of cardiovascular disease. Am J Clin Nutr 2009;90:288-97. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | ALPHA-LINOLENIC ACID ; CONTROLLED CLINICAL-TRIAL ; CORONARY-HEART-DISEASE ; POSTMENOPAUSAL WOMEN ; CARDIOVASCULAR RISK ; SERUM-LIPIDS ; FISH-OIL ; HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS ; LDL-CHOLESTEROL ; FATTY-ACID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268152000008 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/227]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Pan, An,Yu, Danxia,Demark-Wahnefried, Wendy,et al. Meta-analysis of the effects of flaxseed interventions on blood lipids[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2009,90(2):288-297. |
| APA | Pan, An,Yu, Danxia,Demark-Wahnefried, Wendy,Franco, Oscar H.,&Lin, Xu.(2009).Meta-analysis of the effects of flaxseed interventions on blood lipids.AMERICAN JOURNAL OF CLINICAL NUTRITION,90(2),288-297. |
| MLA | Pan, An,et al."Meta-analysis of the effects of flaxseed interventions on blood lipids".AMERICAN JOURNAL OF CLINICAL NUTRITION 90.2(2009):288-297. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。