RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans
文献类型：期刊论文
| 作者 | Wu, Ying; Li, Huaixing（黎怀星）; Loos, Ruth J. F.; Qi, Qibin; Hu, Frank B.; Liu, Yong（刘勇） ; Lin, Xu（林旭）
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| 刊名 | JOURNAL OF LIPID RESEARCH
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| 出版日期 | 2009 |
| 卷号 | 50期号:7页码:1479-1486 |
| 关键词 | Mendelian randomization SNP |
| 通讯作者 | Loos, RJF (reprint author), Addenbrookes Hosp, Inst Metab Sci, MRC, Epidemiol Unit, Cambridge, England. |
| 英文摘要 | We previously found that plasma RBP4 levels were strongly associated with metabolic syndrome components. This study aimed to determine whether RBP4 variants are associated with the metabolic syndrome components and plasma RBP4 levels, and to investigate whether the associations between plasma RBP4 and the metabolic syndrome components are causal. Five tagSNPs were tested for their associations with plasma RBP4 levels and metabolic syndrome components in a population-based sample of 3,210 Chinese Hans. A possible causal relationship between plasma RBP4 levels and hypertriglyceridemia was explored by Mendelian randomization. Plasma RBP4 levels were significantly associated with rs10882273 (beta z -0.10SD[-0.17, -0.03], P = 0.0050), rs3758538 (beta z -0.13SD[-0.24, -0.02], P = 0.0249) in all participants, and with rs17108993 in Shanghai participants (beta z -0.19SD[-0.32, -0.05], P = 0.0061). The single nucleotide polymorphism (SNP) rs3758538 was significantly associated with hypertriglyceridemia (OR 0.62 [0.45-0.85], P = 0.0026) and triglycerides (beta z -0.19SD [20.30, 20.07], P = 0.001) in all participants. In Mendelian randomization analysis, the observed effect size of association between rs3758538 and hypertriglyceridemia was different from the expected effect size (P = 0.0213). This is the first study to show that the RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. However, results of Mendelian randomization do not support the hypothesis thatRBP4 levels are causally related to hypertriglyceridemia risk.-Wu, Y., H. Li, R. J. F. Loos, Q. Qi, F. B. Hu, Y. Liu, and X. Lin. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in ChineseHans. J. Lipid Res. 2009. 50: 1479-1486. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | RETINOL-BINDING PROTEIN-4 ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; SERUM RETINOL-BINDING-PROTEIN-4 ; MENDELIAN RANDOMIZATION ; OBESITY ; DISEASE ; GENE ; COMPONENTS ; TRAITS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266912200022 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/228]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Wu, Ying,Li, Huaixing,Loos, Ruth J. F.,et al. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans[J]. JOURNAL OF LIPID RESEARCH,2009,50(7):1479-1486. |
| APA | Wu, Ying.,Li, Huaixing.,Loos, Ruth J. F..,Qi, Qibin.,Hu, Frank B..,...&Lin, Xu.(2009).RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans.JOURNAL OF LIPID RESEARCH,50(7),1479-1486. |
| MLA | Wu, Ying,et al."RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans".JOURNAL OF LIPID RESEARCH 50.7(2009):1479-1486. |
入库方式： OAI收割
来源：上海营养与健康研究所
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