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Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients
文献类型：期刊论文
| 作者 | Pan, An; Demark-Wahnefried, Wendy; Ye, Xingwang; Yu, Zhijie; Li, Huaixing（黎怀星）; Qi, Qibin; Sun, Jianqin; Chen, Yanqiu; Chen, Xiafei; Liu, Yong（刘勇）
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| 刊名 | BRITISH JOURNAL OF NUTRITION
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| 出版日期 | 2009 |
| 卷号 | 101期号:8页码:1145-1149 |
| 关键词 | Lignan C-reactive protein IL-6 Retinol-binding protein 4 Flaxseed Type 2 diabetes Inflammation |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Elevated C-reactive protein (CRP), IL-6 and retinol-binding protein 4 (RBP4) levels are associated with insulin resistance and diabetes mellitus. Phytoestrogens (including lignans and isoflavones) may enhance the management of diabetes and are hypothesized to act through inflammation pathways. The present study explored the effects of flaxseed-derived lignan on inflammatory factors and RBP4 concentrations in type 2 diabetics, who have higher levels of these biomarkers. Seventy community-dwelling diabetic patients (twenty-six men and forty-four post-menopausal women) with mild hypercholesterolaemia completed a randomized, double-blind, placebo-controlled, cross-over trial of supplementation with flaxseed-derived lignan capsules (360 mg/d) or placebo for 12 weeks, separated by an 8-week wash-out period. The participants maintained their habitual diets and levels of physical activity. Baseline to follow-up concentrations of CRP increased significantly within the placebo group (1.42 (SEM 0.19) v. 1.96 (SEM 0.22) mg/l, P<0.001), but were comparatively unchanged in the lignan-supplemented group (1.67 (SEM 0.19) v. 1.90 (SEM 0.26) mg/l, P=0.94); a significant difference was observed between treatments (-0.45 (95% CI -0.76, -0-08) mg/l, P=0.021). This effect was confined to women (P=0.016), but not observed in men (P=0.49). No between-treatment differences were found with regard to IL-6 or RBP4; though IL-6 concentrations increased significantly from baseline to follow-up in both groups (P=0.004 and P<0.001 following lignan and placebo treatments, respectively). The study suggests that lignan might modulate CRP levels in type 2 diabetics. These results need to be confirmed by further large clinical trials of longer duration. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | HEALTHY POSTMENOPAUSAL WOMEN ; METABOLIC SYNDROME ; SOY ISOFLAVONES ; INFLAMMATORY BIOMARKERS ; DIETARY PHYTOESTROGENS ; SYSTEMIC INFLAMMATION ; CARDIOVASCULAR RISK ; CLINICAL-TRIAL ; DOUBLE-BLIND ; MARKERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000265698700004 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/231]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Pan, An,Demark-Wahnefried, Wendy,Ye, Xingwang,et al. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients[J]. BRITISH JOURNAL OF NUTRITION,2009,101(8):1145-1149. |
| APA | Pan, An.,Demark-Wahnefried, Wendy.,Ye, Xingwang.,Yu, Zhijie.,Li, Huaixing.,...&Lin, Xu.(2009).Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients.BRITISH JOURNAL OF NUTRITION,101(8),1145-1149. |
| MLA | Pan, An,et al."Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients".BRITISH JOURNAL OF NUTRITION 101.8(2009):1145-1149. |
入库方式： OAI收割
来源：上海营养与健康研究所
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