Enterolactone Inhibits Insulin-Like Growth Factor-1 Receptor Signaling in Human Prostatic Carcinoma PC-3 Cells
文献类型：期刊论文
| 作者 | Chen, Li-Hua; Fang, Jing（方靖）; Sun, Zhijian; Li, Huaixing（黎怀星）; Wu, Ying; Demark-Wahnefried, Wendy; Lin, Xu（林旭）
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| 刊名 | JOURNAL OF NUTRITION
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| 出版日期 | 2009 |
| 卷号 | 139期号:4页码:653-659 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China. |
| 英文摘要 | Enterolactone, a major metabolite of plant-based lignans, has been shown to inhibit prostate cancer growth and development, but the mechanistic basis for its anticancer activity remains largely unknown. Activation of insulin-like growth factor-1 (IGF-1) receptor (IGF-1R) signaling is critical for prostate cancer cell growth and progression. This study examined whether the growth inhibitory effect of enterolactone was related to changes in the IGF-1/IGF-1R system in PC-3 prostate cancer cells. At nutritionally relevant concentrations (20-60 mu mol/L), enterolactone inhibited IGF-1-induced activation of IGF-1R and its downstream AKT and mitogen-activated protein kinase/extracellular-signal regulated kinase signaling pathways. Inhibition of AKT by enterolactone resulted in decreased phosphorylation of its downstream targets, including p70S6K1 and glycogen synthase kinase-3 beta. Enterolactone also inhibited cyclin D1 expression. As a result, enterolactone inhibited proliferation and migration of PC-3 cells. Knockdown of IGF-1R by plasmids with siRNA (si) against IGF-1 R mRNA resulted in inhibition of proliferation of PC-3 cells and cell numbers did not differ when the si-IGF-1R groups (cells transfected with plasmids containing siRNA against IGF-1R mRNA) were treated or untreated with enterolactone. These results suggest that enterolactone suppresses proliferation and migration of prostate cancer cells, at least partially, through inhibition of IGF-1/IGF-1R signaling. The finding of this study provides new insights into the molecular mechanisms that enterolactone exerts against prostate cancer. J. Nutr. 139: 653-659, 2009. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | DIETARY-FAT RESTRICTION ; CANCER CELLS ; FLAXSEED SUPPLEMENTATION ; MAMMALIAN LIGNANS ; BINDING PROTEIN-3 ; TRANSGENIC MICE ; IGF-I ; EXPRESSION ; PROLIFERATION ; PROGRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264724400005 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/232]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Chen, Li-Hua,Fang, Jing,Sun, Zhijian,et al. Enterolactone Inhibits Insulin-Like Growth Factor-1 Receptor Signaling in Human Prostatic Carcinoma PC-3 Cells[J]. JOURNAL OF NUTRITION,2009,139(4):653-659. |
| APA | Chen, Li-Hua.,Fang, Jing.,Sun, Zhijian.,Li, Huaixing.,Wu, Ying.,...&Lin, Xu.(2009).Enterolactone Inhibits Insulin-Like Growth Factor-1 Receptor Signaling in Human Prostatic Carcinoma PC-3 Cells.JOURNAL OF NUTRITION,139(4),653-659. |
| MLA | Chen, Li-Hua,et al."Enterolactone Inhibits Insulin-Like Growth Factor-1 Receptor Signaling in Human Prostatic Carcinoma PC-3 Cells".JOURNAL OF NUTRITION 139.4(2009):653-659. |
入库方式： OAI收割
来源：上海营养与健康研究所
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