热门
Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese
文献类型：期刊论文
| 作者 | Sun, Liang（孙亮）; Franco, Oscar H.; Hu, Frank B.; Cai, Lu; Yu, Zhijie; Li, Huaixing（黎怀星）; Ye, Xingwang; Qi, Qibin; Wang, Jing; Pan, An |
| 刊名 | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
 |
| 出版日期 | 2008 |
| 卷号 | 93期号:12页码:4690-4696 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Context: Elevated ferritin concentrations frequently cluster with well-established risk factors of diabetes including obesity, metabolic syndrome, chronic inflammation, and altered circulating adipokines. Few studies, however, have systematically evaluated the effect of these risk factors on ferritin-diabetes association, particularly in Chinese populations. Objective: We aimed to investigate, in a middle-aged and elderly Chinese population, whether elevated ferritin concentrations are associated with higher risk of metabolic syndrome and type 2 diabetes and to what extent the associations were influenced by obesity, inflammation, and adipokines. Design and Methods: We conducted a population-based, cross-sectional survey of 3289 participants aged 50-70 yr in Beijing and Shanghai in 2005. Fasting plasma ferritin, glucose, insulin, lipid profile, glycohemoglobin, inflammatory markers, adipokines, and dietary profile were measured. Results: Median ferritin concentrations were 155.7 ng/ml for men and 111.9 ng/ml for women. After multiple adjustment, the odds ratios (ORs) were substantially higher for type 2 diabetes (OR 3.26, 95% confidence interval 2.36-4.51) and metabolic syndrome [OR 2.80 (95% confidence interval 2.24-3.49)] in the highest ferritin quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for dietary factors, body mass index, inflammatory markers, and adipokines. Conclusions: Elevated circulating ferritin concentrations were associated with higher risk of type 2 diabetes and metabolic syndrome in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors. Our data support the crucial role of iron overload for metabolic diseases, even in a country with relatively high prevalence of iron deficiency. (J Clin Endocrinol Metab 93: 4690-4696, 2008) |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | BODY IRON STORES ; RESISTANCE SYNDROME DESIR ; INSULIN-RESISTANCE ; CARDIOVASCULAR-DISEASE ; SERUM FERRITIN ; OLDER CHINESE ; ASSOCIATION ; OBESITY ; INFLAMMATION ; RISK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261396900016 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/235]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Liang,Franco, Oscar H.,Hu, Frank B.,et al. Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2008,93(12):4690-4696. |
| APA | Sun, Liang.,Franco, Oscar H..,Hu, Frank B..,Cai, Lu.,Yu, Zhijie.,...&Lin, Xu.(2008).Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,93(12),4690-4696. |
| MLA | Sun, Liang,et al."Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 93.12(2008):4690-4696. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。