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Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study
文献类型：期刊论文
| 作者 | Pan, An; Ye, Xingwang; Franco, Oscar H.; Li, Huaixing（黎怀星）; Yu, Zhijie; Zou, Shurong; Zhang, Zheng; Jiao, Shufang; Lin, Xu（林旭）
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| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
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| 出版日期 | 2008 |
| 卷号 | 109期号:1-2页码:75-82 |
| 关键词 | depressive symptoms insulin resistance Chinese CES-D cross-sectional study HOMA-IR |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Background: Depression is associated with an increased risk of incident diabetes, and insulin resistance is thought to be the underlying link between them. Nevertheless, only a few studies have explored the association between insulin resistance and depression with contradictory results, and none have been conducted in Chinese populations. Methods: We aimed to determine the association between insulin resistance and depressive symptoms among middle-aged and elderly Chinese using data from the Nutrition and Health of Aging Population in China Study, a population-based cross-sectional study conducted in 2005 in China. Participants included 3285 community residents aged 50-70 years. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Insulin resistance was calculated using the updated homeostasis model assessment (HOMA2-IR) methods. Results: Value of HOMA2-IR was significantly higher in participants with depressive symptoms (0.284 vs. 0.261, P = 0.008), even after adjustment for various confounding factors in the regression model (0.311 vs. 0.291, P = 0.026). Logistical regression analyses showed that participants with depressive symptoms had a higher risk of having insulin resistance (defined as in the top quartile of HOMA2-IR values, odds ratio = 1.54, 95% confidence intervals = 1.17-2.04). Limitations: Due to the cross-sectional study design, causal relation remains unknown. Conclusions: The present study found positive associations between depressive symptoms and insulin resistance among Chinese populations. Further prospective studies are needed to validate the results and find the temporal and causal relation between them. (C) 2007 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Clinical Neurology ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry |
| 关键词[WOS] | DEPENDENT DIABETES-MELLITUS ; CARDIOVASCULAR-DISEASE ; GLYCEMIC CONTROL ; OBESE PATIENTS ; RISK-FACTORS ; GLUCOSE ; ADULTS ; TYPE-2 ; METAANALYSIS ; ASSOCIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256987300007 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/239]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Pan, An,Ye, Xingwang,Franco, Oscar H.,et al. Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study[J]. JOURNAL OF AFFECTIVE DISORDERS,2008,109(1-2):75-82. |
| APA | Pan, An.,Ye, Xingwang.,Franco, Oscar H..,Li, Huaixing.,Yu, Zhijie.,...&Lin, Xu.(2008).Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study.JOURNAL OF AFFECTIVE DISORDERS,109(1-2),75-82. |
| MLA | Pan, An,et al."Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study".JOURNAL OF AFFECTIVE DISORDERS 109.1-2(2008):75-82. |
入库方式： OAI收割
来源：上海营养与健康研究所
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