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The Association of Depressive Symptoms with Inflammatory Factors and Adipokines in Middle-Aged and Older Chinese
文献类型：期刊论文
| 作者 | Pan, An; Ye, Xingwang; Franco, Oscar H.; Li, Huaixing（黎怀星）; Yu, Zhijie; Wang, Jing; Qi, Qibin; Gu, Wenjia; Pang, Xinghuo; Liu, Hong |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2008 |
| 卷号 | 3期号:1页码:e1392 |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Syst Biol, Shanghai, Peoples R China. |
| 英文摘要 | Background. Studies in Western populations find that depression is associated with inflammation and obesity. The present study aimed to evaluate the relation of depressive symptoms with inflammatory factors and adipose-derived adipokines in middle-aged and older Chinese. Methodology/Principal Findings. Data were from 3289 community residents aged 50-70 from Beijing and Shanghai who participated in the Nutrition and Health of Aging Population in China project. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Plasma concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) were measured. Of the 3289 participants, 312 (9.5%) suffered from current depressive symptoms. IL-6 level was higher in participants with depressive symptoms compared to their counterparts in the crude analyses (1.17 vs. 1.05 pg/mL, p = 0.023) and this association lost statistical significance after multiple adjustments (1.13 vs. 1.10 pg/mL, p = 0.520). Depressive symptoms were not associated with increased mean levels of any other inflammatory factors or adipokines in the unadjusted or adjusted analyses. Conclusions/Significance. We found no evidence that depressive symptoms were associated with inflammatory factors and adipokines in the middle-aged and older Chinese populations. Prospective studies and studies in clinically diagnosed patients are needed to confirm our results and clarify the relation of depression with inflammatory factors and adipokines. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | C-REACTIVE PROTEIN ; CORONARY-HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; ADIPOSE-TISSUE ; MYOCARDIAL-INFARCTION ; METABOLIC SYNDROME ; RISK-FACTORS ; OBESITY ; MARKERS ; PEOPLE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260468900020 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/240]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Pan, An,Ye, Xingwang,Franco, Oscar H.,et al. The Association of Depressive Symptoms with Inflammatory Factors and Adipokines in Middle-Aged and Older Chinese[J]. PLOS ONE,2008,3(1):e1392. |
| APA | Pan, An.,Ye, Xingwang.,Franco, Oscar H..,Li, Huaixing.,Yu, Zhijie.,...&Lin, Xu.(2008).The Association of Depressive Symptoms with Inflammatory Factors and Adipokines in Middle-Aged and Older Chinese.PLOS ONE,3(1),e1392. |
| MLA | Pan, An,et al."The Association of Depressive Symptoms with Inflammatory Factors and Adipokines in Middle-Aged and Older Chinese".PLOS ONE 3.1(2008):e1392. |
入库方式： OAI收割
来源：上海营养与健康研究所
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