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Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
文献类型：期刊论文
| 作者 | Chen, Li-Hua; Fang, Jing（方靖）; Li, Huaixing（黎怀星）; Demark-Wahnefried, Wendy; Lin, Xu（林旭）
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| 刊名 | MOLECULAR CANCER THERAPEUTICS
 |
| 出版日期 | 2007 |
| 卷号 | 6期号:9页码:2581-2590 |
| 通讯作者 | Lin, X (reprint author), Inst Nutr Sci, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | The mammalian lignan enterolactone is a major metabolite of plant-based lignans that has been shown to inhibit the growth and development of prostate cancer. However, little is known about the mechanistic basis for its anticancer activity. In this study, we report that enterolactone selectively suppresses the growth of LNCaP prostate cancer cells by triggering apoptosis. Mechanistic studies showed that enterolactone-induced apoptosis was characterized by a dose-dependent loss of mitochondrial membrane potential, release of cytochrome c and cleavage of procaspase-3 and poly(ADP-ribose)-polymerase (PARP) Caspase dependence was indicated by the ability of the pan-caspase inhibitor z-VAD-fmk to attenuate enterolactone-mediated apoptosis. Mechanistic studies suggested roles for Akt, GSK-3 beta, MDM2, and p53 in enterolactone-dependent apoptosis. Our findings encourage further studies of enterolactone as a promising chemopreventive agent against prostate cancer. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | GLYCOGEN-SYNTHASE KINASE-3 ; CYTOCHROME-C RELEASE ; SERUM ENTEROLACTONE ; MAMMALIAN LIGNANS ; CANCER CELLS ; IN-VITRO ; FLAXSEED SUPPLEMENTATION ; FEEDBACK LOOP ; TUMOR-CELLS ; RYE BRAN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000249716200023 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/245]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Chen, Li-Hua,Fang, Jing,Li, Huaixing,et al. Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway[J]. MOLECULAR CANCER THERAPEUTICS,2007,6(9):2581-2590. |
| APA | Chen, Li-Hua,Fang, Jing,Li, Huaixing,Demark-Wahnefried, Wendy,&Lin, Xu.(2007).Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway.MOLECULAR CANCER THERAPEUTICS,6(9),2581-2590. |
| MLA | Chen, Li-Hua,et al."Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway".MOLECULAR CANCER THERAPEUTICS 6.9(2007):2581-2590. |
入库方式： OAI收割
来源：上海营养与健康研究所
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