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Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans
文献类型：期刊论文
| 作者 | Zhu, Jingwen; Sun, Qi; Zong, Geng; Si, Yuan; Liu, Chen; Qi, Qibin; Ye, Xingwang; Sun, Liang（孙亮）; Sheng, Hongguang; Li, Huaixing（黎怀星） |
| 刊名 | JOURNAL OF LIPID RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 54期号:5页码:1477-1483 |
| 关键词 | fatty acid desaturase 1 delta-5 desaturase high density lipoprotein cholesterol triglycerides |
| 通讯作者 | Li, HX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutrit Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China. |
| 英文摘要 | Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations. In a population-based sample of 3,210 unrelated Han Chinese living in Beijing and Shanghai, we examined a FADS1 genetic variant, rs174550, in relation to blood PUFA and lipid levels. C-allele of rs174550 was significantly associated with levels of erythrocyte PUFAs in upstream and downstream pathways of delta-5 desaturase (D5D) (P <= 0.003). Moreover, rs174550 C-allele was associated with a lower HDL cholesterol level (P = 0.02) in total population and a higher triglyceride level (P = 0.0002) in Beijing residents. Interestingly, erythrocyte levels of 18: 2n-6 and 18: 3n-3 modified the effect of rs174550 on HDL cholesterol level: stronger associations between rs174550 C-allele and lower HDL cholesterol levels were exhibited when erythrocyte 18:2n-6 or 18:3n-3 level was low (P for interaction = 0.02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population.-Zhu, J., Q. Sun, G. Zong, Y. Si, C. Liu, Q. Qi, X. Ye, L. Sun, H. Sheng, H. Li, and X. Lin. Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profi le in Chinese Hans. J. Lipid Res. 2013. 54: 1477-1483. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | PROLIFERATOR-ACTIVATED RECEPTOR ; HDL-CHOLESTEROL CONCENTRATIONS ; FADS1-FADS2 GENE-CLUSTER ; TOTAL-ENERGY-INTAKE ; ADIPOSE-TISSUE ; ASSOCIATION ; DISEASE ; LOCI ; POPULATION ; METABOLISM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317394300032 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/247]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhu, Jingwen,Sun, Qi,Zong, Geng,et al. Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans[J]. JOURNAL OF LIPID RESEARCH,2013,54(5):1477-1483. |
| APA | Zhu, Jingwen.,Sun, Qi.,Zong, Geng.,Si, Yuan.,Liu, Chen.,...&Lin, Xu.(2013).Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.JOURNAL OF LIPID RESEARCH,54(5),1477-1483. |
| MLA | Zhu, Jingwen,et al."Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans".JOURNAL OF LIPID RESEARCH 54.5(2013):1477-1483. |
入库方式： OAI收割
来源：上海营养与健康研究所
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