Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals
文献类型：期刊论文
| 作者 | Yu, D. X.; Sun, Q.; Ye, X. W.; Pan, A.; Zong, G.; Zhou, Y. H.; Li, Huaixing（黎怀星）; Hu, F. B.; Lin, Xu（林旭）.
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| 刊名 | DIABETOLOGIA
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| 出版日期 | 2012 |
| 卷号 | 55期号:11页码:2954-2962 |
| 关键词 | Biomarkers Diet Dyslipidaemia trans-Fatty acids Type 2 diabetes |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2 diabetes and cardiovascular risk factors in Chinese individuals. Erythrocyte fatty acids were measured by gas chromatography among 3,107 men and women (50-70 years) recruited from urban and rural areas in Beijing and Shanghai, China. Total trans-18:1 and two trans-18:2 isomers were detected and accounted for 0.37% of the total fatty acids in the erythrocytes. Concentrations of TFAs were higher in women than men, and in urban than rural residents. Of the TFAs, trans-18:1, but not trans-18:2, showed a modest association with dairy consumption (beta = 0.27), but not with other foods. After adjustment for BMI, social-demographic, lifestyle and dietary factors and other TFAs, erythrocyte trans-18:1 was shown to be associated with a lower risk of type 2 diabetes (OR comparing extreme [first and fourth] quartiles 0.68, 95% CI 0.48, 0.97, p (trend) = 0.02), as well as 20-50% lower odds of central obesity, dyslipidaemia, hyperglycaemia, insulin resistance and chronic inflammation. In contrast, trans-18:2 fatty acids were positively associated with high triacylglycerol (p (trend) < 0.001) and LDL-cholesterol (p (trend) = 0.03) levels, but not with diabetes and other cardiometabolic risk factors. Among middle-aged and older Chinese individuals with overall low erythrocyte TFAs levels, trans-18:1 might serve as a marker of dairy intake. Higher trans-18:1 levels were associated with a lower risk of type 2 diabetes, whereas higher trans-18:2 levels were associated with dyslipidaemia. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | CORONARY-HEART-DISEASE ; C-REACTIVE PROTEIN ; METABOLIC SYNDROME ; ADIPOSE-TISSUE ; DIETARY-FAT ; PLASMA ; HEALTH ; DAIRY ; ASSOCIATION ; ADULTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309561600011 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/248]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Yu, D. X.,Sun, Q.,Ye, X. W.,et al. Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals[J]. DIABETOLOGIA,2012,55(11):2954-2962. |
| APA | Yu, D. X..,Sun, Q..,Ye, X. W..,Pan, A..,Zong, G..,...&Lin, Xu.(2012).Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals.DIABETOLOGIA,55(11),2954-2962. |
| MLA | Yu, D. X.,et al."Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals".DIABETOLOGIA 55.11(2012):2954-2962. |
入库方式： OAI收割
来源：上海营养与健康研究所
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