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Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
文献类型：期刊论文
| 作者 | Li, H.; Kilpelaeinen, T. O.; Liu, C.; Zhu, J.; Liu, Y.; Hu, C.; Yang, Z.; Zhang, W.; Bao, W.; Cha, S. |
| 刊名 | DIABETOLOGIA
 |
| 出版日期 | 2012 |
| 卷号 | 55期号:4页码:981-995 |
| 关键词 | Asians FTO Meta-analysis Obesity Type 2 diabetes |
| 通讯作者 | Lin, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. All studies published on the association between FTO-rs9939609 (or proxy [r (2) > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. The FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 x 10(-19)), overweight by 1.13-fold/allele (p = 1.0 x 10(-11)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 x 10(-8)). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 x 10(-5)). The FTO-rs9939609 minor allele increased BMI by 0.26 kg/m(2) per allele (p = 2.8 x 10(-17)), WHR by 0.003/allele (p = 1.2 x 10(-6)), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12-20%) than South Asians (30-33%), the effect of FTO variation on obesity-related traits and type 2 diabetes was similar in the two populations. FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; BODY-MASS INDEX ; CHINESE POPULATION ; FAT MASS ; JAPANESE POPULATION ; WAIST CIRCUMFERENCE ; ADULT OBESITY ; VARIANTS ; METAANALYSIS ; LOCI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301182000015 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/249]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Li, H.,Kilpelaeinen, T. O.,Liu, C.,et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians[J]. DIABETOLOGIA,2012,55(4):981-995. |
| APA | Li, H..,Kilpelaeinen, T. O..,Liu, C..,Zhu, J..,Liu, Y..,...&Loos, R. J. F..(2012).Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.DIABETOLOGIA,55(4),981-995. |
| MLA | Li, H.,et al."Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians".DIABETOLOGIA 55.4(2012):981-995. |
入库方式： OAI收割
来源：上海营养与健康研究所
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