Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population
文献类型：期刊论文
| 作者 | Qi, Q.; Li, Huaixing（黎怀星）; Wu, Y.; Liu, C.; Wu, H.; Yu, Z.; Qi, L.; Hu, F. B.; Loos, R. J. F.; Lin, Xu（林旭）.
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| 刊名 | DIABETOLOGIA
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| 出版日期 | 2010 |
| 卷号 | 53期号:10页码:2163-2166 |
| 关键词 | Chinese Genetic risk score Genetic variants Population-based study Receiver operating characteristic Type 2 diabetes |
| 通讯作者 | Li, H (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | The recent advent of genome-wide association studies has considerably accelerated the identification of type 2 diabetes loci. We aimed to investigate the combined effects of multiple genetic variants, alone or in combination with conventional risk factors, on type 2 diabetes and diabetes-related traits in Han Chinese. We genotyped 17 variants in 17 loci in a population-based Han Chinese cohort including 3,210 unrelated individuals. A genetic risk score (GRS) was calculated on the basis of these variants. The discriminatory ability was assessed by the area under the receiver operating characteristics curve. The odds ratio for type 2 diabetes and hyperglycaemia with each GRS point (per risk allele) was 1.18 (95% CI 1.12-1.23, p = 1.3 x 10(-12)) and 1.12 (95% CI 1.09-1.16, p = 7.5 x 10(-14)), respectively. Compared with participants with GRS a parts per thousand currency sign11.0 (7.63%), those with GRS a parts per thousand yen19.0 (8.87%) had a 4.58-fold higher risk (95% CI 2.49-8.42) of type 2 diabetes. The GRS also showed a significant association with lower beta cell function estimated by HOMA of beta cell function (p = 8.4 x 10(-10)). In addition, we observed significant interactive effects between GRS and BMI on fasting glucose and HbA(1c) levels (p = 0.04 and p = 0.03 for interaction, respectively). Discrimination of diabetes risk was improved (p < 0.001) when the GRS was added to a model including clinical risk factors. The AUCs were 0.62 and 0.77, respectively, for the GRS and conventional clinic risk factors alone, and 0.79 when the GRS was added. In this Han Chinese population, the GRS of 17 combined variants modestly but significantly improved discrimination of the conventional risk factors for type 2 diabetes. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | IMPAIRED FASTING GLUCOSE ; GENOME-WIDE ASSOCIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281612600013 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/250]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Qi, Q.,Li, Huaixing,Wu, Y.,et al. Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population[J]. DIABETOLOGIA,2010,53(10):2163-2166. |
| APA | Qi, Q..,Li, Huaixing.,Wu, Y..,Liu, C..,Wu, H..,...&Lin, Xu.(2010).Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population.DIABETOLOGIA,53(10),2163-2166. |
| MLA | Qi, Q.,et al."Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population".DIABETOLOGIA 53.10(2010):2163-2166. |
入库方式： OAI收割
来源：上海营养与健康研究所
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